Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9498495 | 0.92 | REN (0.31) | — | |
| Fumaric Acid SCHEMBL9795063 | 0.79 | NOS1 (0.38) | — | |
| SCHEMBL9498615 | 0.78 | — | — | |
| Fumaric Acid SCHEMBL9795500 | 0.72 | PDE5A (0.33) | — | |
| SCHEMBL9501653 | 0.71 | KMT2A (0.33) | — | |
| Fumaric Acid SCHEMBL9795234 | 0.70 | PKM (0.45) | — | |
| Fumaric Acid SCHEMBL9795180 | 0.70 | SMN1; SMN2 (0.42) | — | |
| Fumaric Acid SCHEMBL9795311 | 0.69 | — | — | |
| SCHEMBL9497764 | 0.69 | NOS1 (0.42) | — | |
| Fumaric Acid SCHEMBL9795171 | 0.68 | PTGS1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |