Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of N-Methylanthranilic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| N-Methylanthranilic Acid SCHEMBL10796611 | 0.96 | KDM4E (0.60) | KDM4EPOLBATMALDH1A1HPGD | |
| N-Methylanthranilic Acid SCHEMBL9616094 | 0.81 | KDM4E (0.45) | KDM4EPOLBATMALDH1A1HPGD | |
| SCHEMBL8628627 | 0.80 | POLB (0.67) | KDM4EPOLBATMALDH1A1HPGD | |
| Potassium Ion SCHEMBL28560618 | 0.78 | FABP4 (0.52) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL31087257 | 0.78 | POLB (0.64) | KDM4EPOLBATMALDH1A1HPGD | |
| SCHEMBL6964053 | 0.78 | KDM4E (0.64) | KDM4EPOLBATMALDH1A1HPGD | |
| SCHEMBL9691887 | 0.78 | HPGD (0.56) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| N-Methylanthranilic Acid SCHEMBL29381752 | 0.78 | KDM4E (0.64) | KDM4EPOLBATMALDH1A1HPGD | |
| SCHEMBL848499 | 0.78 | POLB (0.64) | KDM4EPOLBATMALDH1A1HPGD | |
| N-Methylanthranilic Acid SCHEMBL130356 | 0.78 | KDM4E (0.64) | KDM4EPOLBATMALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182373-A2 | Blood coagulation tests on reagent-strips | Roche Diagnostics GmbH (DE) | 1986-05-28 | — | — | EP | claimed |
| US-5059525-A | Test strips; protease; chromophoric substrate; buffer; oxidizing agent | BOEHRINGER MANNHEIM GMBH (DE) | 1991-10-22 | — | — | US | disclosed |
| EP-0182373-B1 | BLOOD COAGULATION TESTS ON REAGENT-STRIPS | Roche Diagnostics GmbH (DE) | 1991-03-27 | — | — | EP | disclosed |