Sugi Predict

Sugi Predict / Compounds / SCHEMBL980277

SCHEMBL980277

SCHEMBL980277

COc1ccc(-c2cccc(N)c2)cc1OC

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ NTRK1 P04629 1/20 0.58
▸ KIT P10721 1/20 0.58
▸ ALDH1A1 P00352 2/20 0.53
▸ CYP3A4 P08684 2/20 0.53
▸ HSD17B10 Q99714 2/20 0.53
▸ TSHR P16473 1/20 0.53
▸ TDP1 Q9NUW8 1/20 0.53
▸ MAOA P21397 1/20 0.52
▸ FYN P06241 3/20 0.50
▸ PDE4A P27815 1/20 0.48
▸ F9 P00740 1/20 0.48
▸ NPC1 O15118 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ ADORA1 P30542 1/20 0.47
▸ MEN1 O00255 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ KDM4E B2RXH2 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3784708 0.87 ALDH1A1 (0.74) NTRK1KITALDH1A1CYP3A4HSD17B10
SCHEMBL3783522 0.87 ALDH1A1 (0.52) NTRK1KITALDH1A1CYP3A4HSD17B10
SCHEMBL16541896 0.86 PDE4A (0.57) ALDH1A1CYP3A4HSD17B10TSHRTDP1
SCHEMBL980044 0.85 MAP4K4 (0.51) NTRK1KITALDH1A1CYP3A4HSD17B10
SCHEMBL21116012 0.84 ADORA2A (0.50) NTRK1KITALDH1A1CYP3A4HSD17B10
SCHEMBL7140279 0.82 ALDH1A1 (0.59) KITALDH1A1CYP3A4HSD17B10TSHR
SCHEMBL30610431 0.82 ALDH1A1 (0.59) KITALDH1A1CYP3A4HSD17B10TSHR
SCHEMBL6798284 0.82 PDE4A (0.65) PDE4A
SCHEMBL27981291 0.81 ERN1 (0.50) ALDH1A1CYP3A4HSD17B10TSHRTDP1
SCHEMBL8840880 0.81 PDE4A (0.67) ALDH1A1CYP3A4HSD17B10TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108299428-B 8- amido -7- methyl formate-pyrazine a pair of horses going side by side Pyridione derivatives and the preparation method and application thereof 山东大学 2019-09-27 — — CN claimed
CN-108299428-A 8- amidos -7- methyl formates-pyrazine a pair of horses going side by side Pyridione derivatives and the preparation method and application thereof 山东大学 2018-07-20 — — CN claimed
US-10752624-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2020-08-25 — — US disclosed
CN-108299428-B 8- amido -7- methyl formate-pyrazine a pair of horses going side by side Pyridione derivatives and the preparation method and application thereof 山东大学 2019-09-27 — — CN disclosed
US-20180305356-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2018-10-25 — — US disclosed
CN-108299428-A 8- amidos -7- methyl formates-pyrazine a pair of horses going side by side Pyridione derivatives and the preparation method and application thereof 山东大学 2018-07-20 — — CN disclosed
US-10000482-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2018-06-19 — — US disclosed
US-9802937-B2 Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-10-31 — — US disclosed
US-9637491-B2 Pyrazolo[4,3-D]pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-05-02 — — US disclosed
US-9579320-B2 Inhibitors of syk and JAK protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2017-02-28 — — US disclosed
US-9499535-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2016-11-22 — — US disclosed
US-20120101275-A1 INHIBITORS OF SYK AND JAK PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. (US) 2012-04-26 — — US disclosed
US-8063058-B2 Inhibitors of syk and JAK protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2011-11-22 — — US disclosed
US-8063058-B2 Inhibitors of syk and JAK protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2011-11-22 — — US disclosed
US-20110021522-A1 ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-01-27 — — US disclosed
EP-2237784-A1 ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 The Regents of the University of California (US) 2010-10-13 — — EP disclosed
US-20100048567-A1 Inhibitors of syk and JAK protein kinases PORTOLA PHARMACEUTICALS INC. (US) 2010-02-25 — — US disclosed
US-20100048567-A1 Inhibitors of syk and JAK protein kinases PORTOLA PHARMACEUTICALS INC. (US) 2010-02-25 — — US disclosed
WO-2009136995-A2 INHIBITORS OF SYK PROTEIN KINASE PORTOLA PHARMACEUTICALS, INC. (US) 2009-11-12 — — WO disclosed
WO-2009089508-A1 ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-07-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180305356-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK NTRK1 1051/4885KIT 377/4885ALDH1A1 4333/4885
US-20120101275-A1 INHIBITORS OF SYK AND JAK PROTEIN KINASES SYK, BTK, JAK1 NTRK1 1678/4885KIT 292/4885ALDH1A1 3700/4885
US-20110021522-A1 ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 CASP7, CASP3, CASP6 NTRK1 4677/4885KIT 1579/4885ALDH1A1 2806/4885
US-20100048567-A1 Inhibitors of syk and JAK protein kinases SYK, BTK, JAK1 NTRK1 1678/4885KIT 292/4885ALDH1A1 3700/4885
US-10000482-B2 Kinase inhibitors LRRK2, MYLK2, MYLK NTRK1 1060/4885KIT 345/4885ALDH1A1 4184/4885
US-10752624-B2 Kinase inhibitors LRRK2, MYLK2, MYLK NTRK1 1060/4885KIT 345/4885ALDH1A1 4184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.