Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 1.00 |
| ▸ | MIF | P14174 | 9/20 | 0.81 |
| ▸ | MAPT | P10636 | 4/20 | 0.81 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.77 |
| ▸ | PKM | P14618 | 2/20 | 0.77 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | MAOA | P21397 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CASP3 | P42574 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.68 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.68 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15153677 | 1.00 | MAOB (1.00) | MAOBMIFMAPTCYP19A1PKM | |
| SCHEMBL29546087 | 1.00 | MAOB (1.00) | MAOBMIFMAPTCYP19A1PKM | |
| SCHEMBL29546151 | 1.00 | MAOB (1.00) | MAOBMIFMAPTCYP19A1PKM | |
| SCHEMBL29679848 | 1.00 | MAOB (1.00) | MAOBMIFMAPTCYP19A1PKM | |
| SCHEMBL820654 | 1.00 | MAOB (1.00) | MAOBMIFMAPTCYP19A1PKM | |
| SCHEMBL6958006 | 0.90 | MIF (1.00) | MAOBMIFMAPTCYP19A1PKM | |
| SCHEMBL13203410 | 0.90 | MAOB (0.81) | MAOBMIFMAPTCYP19A1PKM | |
| SCHEMBL14033869 | 0.90 | MAOB (0.81) | MAOBMIFMAPTCYP19A1PKM | |
| SCHEMBL8548101 | 0.87 | MAOB (0.77) | MAOBMIFMAPTCYP19A1PKM | |
| SCHEMBL6825622 | 0.87 | CYP19A1 (1.00) | MAOBMIFMAPTCYP19A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104211642-B | The synthesis and the application in cancer therapy drug of pyrazoline sulphone amide derivative of one class containing tetrahydronaphthalene or chroman skeleton | 南京大学 | 2017-10-20 | — | — | CN | claimed |
| CN-104211642-A | Synthesis of dihydropyrazol sulfanilamide derivatives containing tetrahydronaphthalene or chroman framework and application of derivatives in anti-cancer drugs | NANJING UNIVERSITY OF TECHNOLOGY | 2014-12-17 | — | — | CN | claimed |
| US-7166274-B2 | Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds | L'OREAL (FR) | 2007-01-23 | — | — | US | claimed |
| US-20040047820-A1 | Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds | SOCIETE L'OREAL S.A. (FR) | 2004-03-11 | — | — | US | claimed |
| US-6627180-B2 | Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone | SOCIETE L'OREAL S.A. (FR) | 2003-09-30 | — | — | US | claimed |
| US-20030152532-A1 | SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS | SOCIETE L'OREAL S.A. (FR) | 2003-08-14 | — | — | US | claimed |
| CN-115925530-B | 3, 4-dihydronaphthalene-1 (2H) -one compound, preparation method and application | 滨州医学院 | 2024-03-12 | — | — | CN | disclosed |
| US-11661407-B2 | Process for the preparation of pyrylium salts | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2023-05-30 | — | — | US | disclosed |
| CN-115925530-A | 3,4-dihydronaphthalene-1 (2H) -ketone compound, preparation method and application | 滨州医学院 | 2023-04-07 | — | — | CN | disclosed |
| CN-112694449-B | Asymmetric hydrogenation of ketone and alpha, beta-unsaturated ketone catalyzed by nonmetal catalyst | 中国科学院化学研究所 | 2022-05-24 | — | — | CN | disclosed |
| US-11312694-B2 | Method for making propenamide compound | KING ABDULAZIZ UNIVERSITY (SA) | 2022-04-26 | — | — | US | disclosed |
| EP-3561876-B1 | DISPLAY | NOVALED GMBH (DE) | 2022-02-16 | — | — | EP | disclosed |
| US-20220033368-A1 | METHOD FOR MAKING PROPENAMIDE COMPOUND | KING ABDULAZIZ UNIVERSITY (SA) | 2022-02-03 | — | — | US | disclosed |
| US-6627180-B2 | Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone | SOCIETE L'OREAL S.A. (FR) | 2003-09-30 | — | — | US | disclosed |
| US-20030152532-A1 | SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS | SOCIETE L'OREAL S.A. (FR) | 2003-08-14 | — | — | US | disclosed |
| US-20030027830-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2003-02-06 | — | — | US | disclosed |
| US-6462075-B1 | USE OF CHALCONE AND ITS DERIVATIVES AS ANTITUMOR/ANTICANCER AGENTS AND TO TREAT A NUMBER OF CONDITIONS OR DISEASE STATES IN WHICH ANGIOGENESIS IS A FACTOR INCLUDING PSORIASIS, ACNE, ROSACEA, WARTS, ECZEMA, HEMANGIOMAS AND LYMPHANGIOGENESIS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2002-10-08 | — | — | US | disclosed |
| US-20020040029-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | BOWEN, J. PHILLIP | 2002-04-04 | — | — | US | disclosed |
| EP-0015156-A1 | Basically-substituted tricyclic pyrazoles, their preparation and their use as antiinflammatory agents | E.R. Squibb & Sons, Inc. (US) | 1980-09-03 | — | — | EP | disclosed |
| US-4173634-A | Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents | E. R. SQUIBB & SONS, INC. (US) | 1979-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020040029-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | FLT1, FLT4, VEGFA | MAOB 2579/4885MIF 534/4885MAPT 1111/4885 |
| US-20030027830-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | FLT1, VEGFA, FLT4 | MAOB 1509/4885MIF 220/4885MAPT 341/4885 |
| US-20040047820-A1 | Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds | SUCLG1, CUTA, DLD | MAOB 1776/4885MIF 3072/4885MAPT 2067/4885 |
| US-11312694-B2 | Method for making propenamide compound | APC, CYP2C19, PKD1 | MAOB 790/4885MIF 4397/4885MAPT 3739/4885 |
| US-20220033368-A1 | METHOD FOR MAKING PROPENAMIDE COMPOUND | APC, CYP2C19, PKD1 | MAOB 790/4885MIF 4397/4885MAPT 3739/4885 |
| US-11661407-B2 | Process for the preparation of pyrylium salts | SF3B5, IPO5, CYP4F11 | MAOB 2613/4885MIF 1345/4885MAPT 2455/4885 |
| US-20030152532-A1 | SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS | HADHB, SDHA, ERCC4 | MAOB 1274/4885MIF 2357/4885MAPT 922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.