SCHEMBL9816210

SCHEMBL9816210

C=CC(N)[Si](c1ccccc1)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 2/20 0.33
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
F2 P00734 1/20 0.33
EPHX1 P07099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9816218 0.74 CYP2C19 (0.30)
SCHEMBL11500825 0.64 ALDH1A1 (0.33) DPP4ALDH1A1TSHRF2EPHX1
SCHEMBL1534125 0.64 DPP4 (0.50) DPP4ALDH1A1TSHRF2
SCHEMBL1683556 0.64 DPP4 (0.50) DPP4ALDH1A1TSHRF2
SCHEMBL38740 0.64 DPP4 (0.50) DPP4ALDH1A1TSHRF2
SCHEMBL6781917 0.63 ALDH1A1 (0.35) ALDH1A1TSHR
SCHEMBL4430703 0.62 ADRA2A (0.43) DPP4ALDH1A1F2
SCHEMBL1477747 0.62 TSHR (0.41) ALDH1A1TSHR
SCHEMBL5881431 0.62 TSHR (0.41) ALDH1A1TSHR
SCHEMBL381401 0.62 LMNA (0.37) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4994591-A Antitumor, anticarcinogenic agents THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NY (US) 1991-02-19 US claimed
US-4994591-A Antitumor, anticarcinogenic agents THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NY (US) 1991-02-19 US disclosed
US-4994591-A Antitumor, anticarcinogenic agents THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NY (US) 1991-02-19 US disclosed