Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 8/20 | 0.47 |
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819424 | 0.88 | BCL2A1 (0.49) | ADRA1BHTR1AMAPTKMT2AALDH1A1 | |
| SCHEMBL11427937 | 0.84 | ADRA1B (0.44) | ADRA1BHTR1AMAPTKMT2AALDH1A1 | |
| SCHEMBL9819404 | 0.81 | MGLL (0.47) | ADRA1BHTR1AMAPTKMT2AALDH1A1 | |
| SCHEMBL8155583 | 0.80 | KMT2A (0.62) | ADRA1BHTR1AMAPTKMT2AALDH1A1 | |
| SCHEMBL9819315 | 0.79 | MAPT (0.48) | ADRA1BHTR1AMAPTKMT2AALDH1A1 | |
| SCHEMBL9819453 | 0.78 | ALDH1A1 (0.49) | MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL11431742 | 0.77 | OPRK1 (0.47) | ADRA1BHTR1AMAPTKMT2AOPRK1 | |
| SCHEMBL9819370 | 0.77 | KMT2A (0.53) | MAPTKMT2AALDH1A1MEN1BCL2A1 | |
| SCHEMBL9819508 | 0.77 | KMT2A (0.50) | MAPTKMT2AALDH1A1MEN1BCL2A1 | |
| SCHEMBL9819237 | 0.76 | BCL2A1 (0.49) | HTR1AALDH1A1P2RX7BCL2A1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162669-B1 | ANTICONVULSIVE COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| US-4588729-A | Treating convulsions with dihydrouracil derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1986-05-13 | — | — | US | disclosed |
| EP-0162669-A2 | Anticonvulsive compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-11-27 | — | — | EP | disclosed |