Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.52 |
| ▸ | DRD3 | P35462 | 12/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25575682 | 0.84 | L3MBTL1 (0.54) | DRD2DRD3ALDH1A1MAPTALOX5 | |
| SCHEMBL9819344 | 0.83 | DRD2 (0.48) | DRD2DRD3ALDH1A1LMNAMAPT | |
| SCHEMBL9819272 | 0.83 | SLC6A2 (0.56) | DRD2DRD3KCNH2HTR2AMEN1 | |
| SCHEMBL6418503 | 0.82 | MEN1 (0.59) | DRD2DRD3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6401082 | 0.81 | DRD2 (0.47) | DRD2DRD3KCNH2DRD4HTR2A | |
| SCHEMBL9819263 | 0.81 | PKM (0.50) | ALDH1A1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL9819261 | 0.80 | DRD2 (0.54) | DRD2DRD3KCNH2ALDH1A1MAPT | |
| SCHEMBL9819213 | 0.77 | KMT2A (0.43) | MAPTALOX12MEN1KMT2A | |
| SCHEMBL9819189 | 0.76 | SRD5A1 (0.44) | LMNAKMT2A | |
| SCHEMBL9819370 | 0.75 | KMT2A (0.53) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162669-B1 | ANTICONVULSIVE COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| US-4588729-A | Treating convulsions with dihydrouracil derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1986-05-13 | — | — | US | disclosed |
| EP-0162669-A2 | Anticonvulsive compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-11-27 | — | — | EP | disclosed |