SCHEMBL25575682

SCHEMBL25575682

Cc1cccc(N2CCC(=O)N(C)C2=O)c1

nearest known ligand 0.60

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.54
DRD2 P14416 1/20 0.52
DRD3 P35462 1/20 0.52
ALOX5 P09917 3/20 0.48
HSD11B1 P28845 3/20 0.45
MAPT P10636 2/20 0.45
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
HPGD P15428 1/20 0.45
HSP90AA1 P07900 1/20 0.44
MGLL Q99685 1/20 0.44
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9564052 0.85 L3MBTL1 (0.62) L3MBTL1DRD2DRD3ALOX5HSD11B1
SCHEMBL9819448 0.84 DRD2 (0.52) DRD2DRD3ALOX5MAPTALDH1A1
SCHEMBL6401435 0.83 L3MBTL1 (0.53) L3MBTL1DRD2DRD3ALOX5HSD11B1
SCHEMBL6418503 0.82 MEN1 (0.59) DRD2DRD3HSD11B1MAPTALDH1A1
SCHEMBL9819261 0.80 DRD2 (0.54) DRD2DRD3ALOX5MAPTKDM4E
SCHEMBL8256209 0.79 DRD2 (0.59) L3MBTL1DRD2DRD3ALOX5HSD11B1
SCHEMBL9819263 0.78 PKM (0.50) L3MBTL1MAPTKDM4EALDH1A1HPGD
SCHEMBL9819272 0.76 SLC6A2 (0.56) DRD2DRD3
SCHEMBL1750871 0.76 L3MBTL1 (0.56) L3MBTL1DRD2DRD3ALOX5HSD11B1
SCHEMBL1459903 0.76 ALDH1A1 (0.62) L3MBTL1DRD2DRD3ALOX5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4194457-A1 COMPOUND FOR TARGETING AND DEGRADING PROTEIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Leadingtac Pharmaceutical Co., Ltd. (CN) 2023-06-14 EP disclosed