Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824965 | 0.78 | HRH3 (0.33) | HRH3HRH4ACHEALDH1A1PKM | |
| SCHEMBL9036766 | 0.77 | SIGMAR1 (0.40) | HRH3HRH4SIGMAR1MCHR1 | |
| SCHEMBL9824121 | 0.74 | GNAI3 (0.40) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL9823863 | 0.73 | GNAI3 (0.42) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL27267877 | 0.72 | NOS3 (0.38) | HRH3HRH4SIGMAR1MCHR1 | |
| SCHEMBL23128851 | 0.71 | NCF1 (0.45) | ALDH1A1NCF1SIGMAR1MCHR1 | |
| SCHEMBL9824407 | 0.70 | CHRM5 (0.50) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL13280102 | 0.70 | ADRA1B (0.44) | HRH3HRH4ALDH1A1SIGMAR1ADH1C | |
| SCHEMBL13711904 | 0.70 | ADRA1B (0.48) | HRH3HRH4SIGMAR1ADH1CADH1A | |
| SCHEMBL19720283 | 0.70 | ADRA1B (0.48) | HRH3HRH4SIGMAR1ADH1CADH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |