Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825337 | 0.85 | SLC15A1 (0.36) | SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL9826136 | 0.85 | SLC15A1 (0.33) | SMN1; SMN2ALDH1A1L3MBTL1LMNACYP2C19 | |
| SCHEMBL9826400 | 0.85 | SLC15A1 (0.36) | SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL9825737 | 0.83 | SLC15A1 (0.34) | SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL4598760 | 0.73 | TGM2 (0.45) | SMN1; SMN2LMNASIGMAR1CYP2C19ITGB3 | |
| SCHEMBL9826162 | 0.73 | ITGB3 (0.37) | SMN1; SMN2ALDH1A1L3MBTL1LMNASIGMAR1 | |
| SCHEMBL9825547 | 0.72 | KMT2A (0.33) | — | |
| SCHEMBL9826251 | 0.72 | L3MBTL1 (0.37) | SMN1; SMN2ALDH1A1L3MBTL1SIGMAR1CYP2C19 | |
| SCHEMBL8175816 | 0.69 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1LMNAHTTMAPT | |
| SCHEMBL11203786 | 0.69 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1LMNASIGMAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |