Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677172 | 0.83 | JAK2 (0.47) | JAK2JAK3HDAC1ALDH1A1PTK2 | |
| SCHEMBL9828873 | 0.80 | ALDH1A1 (0.40) | JAK2JAK3ALDH1A1PTK2PDE10A | |
| SCHEMBL9829198 | 0.78 | SLC18A3 (0.40) | ALDH1A1MAPTADRA1AKMT2AGAA | |
| SCHEMBL9828313 | 0.78 | JAK2 (0.47) | JAK2JAK3HDAC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9827933 | 0.76 | SLC18A3 (0.46) | ALDH1A1HRH3LMNAMAPTMEN1 | |
| SCHEMBL10577832 | 0.74 | GRIN2B (0.43) | HDAC1ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL10579790 | 0.74 | ADRB2 (0.47) | LMNAMEN1KMT2AGAA | |
| SCHEMBL319380 | 0.74 | KEAP1 (0.52) | ALDH1A1HRH3SMN1; SMN2LMNATP53 | |
| SCHEMBL22324953 | 0.71 | ROCK2 (0.40) | JAK2JAK3HDAC1ALDH1A1PTK2 | |
| SCHEMBL26154175 | 0.71 | ALDH1A1 (0.56) | ALDH1A1HRH3SMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291210-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-4835165-A | Antiarrhythmic 4-phenylpiperidines | PFIZER INC. (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0291210-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-11-17 | — | — | EP | disclosed |