Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828154 | 0.87 | LMNA (0.46) | CHEK1ADORA3MEN1MAPTRAB9A | |
| SCHEMBL9828844 | 0.85 | CHEK1 (0.50) | CHEK1MEN1MAPTRAB9ANPC1 | |
| SCHEMBL9829354 | 0.84 | CHEK1 (0.43) | CHEK1ADORA3MEN1MAPTRAB9A | |
| SCHEMBL9829126 | 0.82 | CHEK1 (0.40) | CHEK1ADORA3ADORA2BMEN1MAPT | |
| SCHEMBL9828939 | 0.82 | MGAM (0.47) | CHEK1MEN1MAPTRAB9ANPC1 | |
| SCHEMBL9828617 | 0.81 | ALDH1A1 (0.51) | CHEK1MEN1MAPTRAB9ANPC1 | |
| SCHEMBL9828641 | 0.78 | MAPT (0.47) | MEN1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL9827533 | 0.78 | NPC1 (0.46) | GRIN2BADORA3MEN1MAPTRAB9A | |
| SCHEMBL9832501 | 0.78 | TLR8 (0.51) | CHEK1MAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL9829232 | 0.74 | FYN (0.44) | CHEK1MEN1MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233804-B1 | MONOARYL-5-AS TRIAZINONES SUBSTITUTED IN POSITION 2, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | PIERRE FABRE MEDICAMENT (FR) | 1991-09-25 | — | — | EP | claimed |