SCHEMBL983024

SCHEMBL983024

COC(=O)c1n[nH]cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.46
ALDH1A1 P00352 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
KDM4C Q9H3R0 1/20 0.43
KDM4E B2RXH2 3/20 0.42
STAT3 P40763 1/20 0.42
HIF1A Q16665 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.41
MAPT P10636 2/20 0.39
F2 P00734 2/20 0.39
KMT2A Q03164 2/20 0.39
HPGD P15428 1/20 0.39
NR4A2 P43354 3/20 0.39
MAPK1 P28482 1/20 0.39
ALPL P05186 3/20 0.39
HSD17B10 Q99714 1/20 0.38
PKM P14618 2/20 0.37
RCE1 Q9Y256 1/20 0.37
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL983844 0.79 L3MBTL1 (0.48) NPSR1ALDH1A1L3MBTL1KDM4EMAPT
SCHEMBL20567149 0.79 LMNA (0.40) NPSR1ALDH1A1KMT2A
SCHEMBL15701735 0.79
SCHEMBL19763311 0.78 KDM4C (0.48) NPSR1ALDH1A1L3MBTL1KDM4CKDM4E
SCHEMBL69295 0.78 NPSR1 (0.48) NPSR1ALDH1A1L3MBTL1KDM4CKDM4E
SCHEMBL5761874 0.78 NPSR1 (0.48) NPSR1ALDH1A1L3MBTL1KDM4CKDM4E
SCHEMBL2658385 0.77
SCHEMBL950773 0.77
SCHEMBL15051421 0.77 GAA (0.49) ALDH1A1L3MBTL1KDM4ESTAT3HIF1A
SCHEMBL13726965 0.76 NPSR1 (0.46) NPSR1ALDH1A1L3MBTL1KDM4CKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4739393-A1 TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS Merck Sharp & Dohme LLC (US) 2026-05-13 EP disclosed
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF SIRONAX LTD (KY) 2026-03-19 US disclosed
EP-4590674-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd (KY) 2025-07-30 EP disclosed
US-20250026759-A1 TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS MERCK SHARP & DOHME LLC (US) 2025-01-23 US disclosed
WO-2025014788-A1 TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS MERCK SHARP & DOHME LLC (US) 2025-01-16 WO disclosed
US-20240182445-A1 MODULATORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION ONO PHARMACEUTICAL CO., LTD. (JP) 2024-06-06 US disclosed
WO-2024061340-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2024-03-28 WO disclosed
EP-4048659-A1 MODULATORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION ONO Pharmaceutical Co., Ltd. (JP) 2022-08-31 EP disclosed
WO-2021080015-A1 MODULATORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION ONO PHARMACEUTICAL CO., LTD. (JP) 2021-04-29 WO disclosed
WO-2021080015-A1 MODULATORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION ONO PHARMACEUTICAL CO., LTD. (JP) 2021-04-29 WO disclosed
US-20210101885-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. 2021-04-08 US disclosed
US-10787437-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor ARENA PHARMACEUTICALS, INC. (US) 2020-09-29 US disclosed
US-20190023691-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. 2019-01-24 US disclosed
US-10059691-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor ARENA PHARMACEUTICALS, INC. (US) 2018-08-28 US disclosed
US-20170137408-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. 2017-05-18 US disclosed
US-9556149-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor ARENA PHARMACEUTICALS, INC. (US) 2017-01-31 US disclosed
US-20150045372-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. 2015-02-12 US disclosed
WO-2012126791-A1 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2012-09-27 WO disclosed
US-20110021538-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. (US) 2011-01-27 US disclosed
WO-2009123714-A2 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. (US) 2009-10-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10787437-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor HTR5A, HTR2A, HTR3A NPSR1 33/4885ALDH1A1 1106/4885L3MBTL1 4884/4885
US-20150045372-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A NPSR1 33/4885ALDH1A1 1106/4885L3MBTL1 4884/4885
US-20170137408-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A NPSR1 33/4885ALDH1A1 1106/4885L3MBTL1 4884/4885
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF NAMPT, NNMT, SARM1 NPSR1 298/4885ALDH1A1 2719/4885L3MBTL1 2991/4885
US-20210101885-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A NPSR1 33/4885ALDH1A1 1106/4885L3MBTL1 4884/4885
US-20240182445-A1 MODULATORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION KCNJ11, KCNJ1, KCNJ2 NPSR1 2573/4885ALDH1A1 2944/4885L3MBTL1 2910/4885
US-20190023691-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A NPSR1 33/4885ALDH1A1 1106/4885L3MBTL1 4884/4885
US-20250026759-A1 TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS ACIN1, REV1, NFATC1 NPSR1 4707/4885ALDH1A1 3081/4885L3MBTL1 1341/4885
US-20110021538-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A NPSR1 33/4885ALDH1A1 1106/4885L3MBTL1 4884/4885
US-10059691-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor HTR5A, HTR2A, HTR3A NPSR1 33/4885ALDH1A1 1106/4885L3MBTL1 4884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.