Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830890 | 0.92 | SMN1; SMN2 (0.43) | NLRP3SMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL31167579 | 0.78 | CYP4F2 (0.55) | NLRP3SMN1; SMN2MAPTALDH1A1HSD17B10 | |
| SCHEMBL18018512 | 0.78 | CYP4F2 (0.55) | NLRP3SMN1; SMN2MAPTALDH1A1HSD17B10 | |
| SCHEMBL9830888 | 0.77 | SMN1; SMN2 (0.50) | NLRP3SMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL9829941 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AKDM4EBCHE | |
| SCHEMBL9832835 | 0.77 | ALDH1A1 (0.47) | ALDH1A1HSD17B10MEN1KMT2AKDM4E | |
| SCHEMBL9831566 | 0.77 | NLRP3 (0.44) | NLRP3SMN1; SMN2MAPTALDH1A1HSD17B10 | |
| SCHEMBL9831610 | 0.76 | ACHE (0.53) | SMN1; SMN2CYP4F2CYP4A11BCHEACHE | |
| SCHEMBL4321470 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1POLBHSD17B10KMT2A | |
| SCHEMBL9832189 | 0.76 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |