Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 10/20 | 0.54 |
| ▸ | ESR1 | P03372 | 6/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837184 | 0.83 | ESR1 (0.52) | ESR2ESR1MAOAEGFRKDM5A | |
| SCHEMBL9835933 | 0.79 | PTGS2 (0.71) | ESR2MAOAMAOBKDM5AKDM4E | |
| SCHEMBL9837057 | 0.77 | SRD5A1 (0.47) | ESR2ESR1MAOAEGFRKDM5A | |
| SCHEMBL9835769 | 0.76 | FHIT (0.52) | MAOAMAOBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15477703 | 0.76 | ATP1A1 (0.64) | ESR2ESR1CA12CA9MAOA | |
| SCHEMBL9836158 | 0.73 | MEN1 (0.58) | ESR2ESR1MAOAKDM4EALDH1A1 | |
| SCHEMBL9836863 | 0.72 | MAOA (0.64) | ESR2ESR1CA12CA9MAOA | |
| SCHEMBL149545 | 0.71 | MAOA (0.73) | MAOAEGFRMAOBKDM5AKDM4E | |
| SCHEMBL7375249 | 0.70 | CA12 (0.56) | ESR2ESR1CA12CA9MAOB | |
| SCHEMBL9836115 | 0.70 | ESR2 (0.51) | ESR2ESR1MAOAEGFRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175376-B1 | XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4816479-A | HYPOTENSIVE AGENTS, DIURETICS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1989-03-28 | — | — | US | disclosed |
| US-4661607-A | ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-04-28 | — | — | US | disclosed |
| EP-0175376-A2 | Xanthone derivatives and process for producing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-03-26 | — | — | EP | disclosed |