Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | SI | P14410 | 5/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.36 |
| ▸ | ENTPD5 | O75356 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30513267 | 0.75 | AKT1 (0.56) | AKT1MGAMGAASIMGAM2 | |
| SCHEMBL3184205 | 0.75 | AKT1 (0.56) | AKT1MGAMGAASIMGAM2 | |
| SCHEMBL11705856 | 0.73 | AKT1 (0.55) | AKT1MGAMGAASIMGAM2 | |
| SCHEMBL11343263 | 0.71 | AKT1 (0.50) | AKT1ENTPD5ESR1ESR2CETP | |
| SCHEMBL8653315 | 0.71 | AKT1 (0.50) | AKT1MGAMGAASIMGAM2 | |
| SCHEMBL7787622 | 0.71 | AKT1 (0.51) | AKT1MGAMGAASIMGAM2 | |
| SCHEMBL21346943 | 0.71 | AKT1 (0.46) | AKT1MGAMGAASIMGAM2 | |
| SCHEMBL9749407 | 0.70 | AKT1 (0.51) | AKT1MGAMGAASIMGAM2 | |
| SCHEMBL10706197 | 0.69 | AKT1 (0.47) | AKT1MGAMGAASIMGAM2 | |
| SCHEMBL4194290 | 0.69 | AKT1 (0.60) | AKT1MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420570-A2 | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis | MERCK & CO. INC. (US) | 1991-04-03 | — | — | EP | disclosed |