Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303256 | 0.90 | GAA (0.45) | DRD3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9302130 | 0.87 | HTT (0.47) | DRD3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9847735 | 0.82 | HTT (0.43) | DRD3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9303370 | 0.81 | ALDH1A1 (0.43) | DRD3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9301127 | 0.81 | DRD3 (0.39) | DRD3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9302147 | 0.76 | GAA (0.41) | DRD3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9302880 | 0.76 | HTT (0.46) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| Acetic Acid SCHEMBL9301936 | 0.75 | CYP11B2 (0.44) | DRD3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9302311 | 0.73 | CYP11B2 (0.44) | DRD3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9301930 | 0.73 | HTT (0.45) | DRD3KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433648-A1 | Substituted pyrimidobenzimidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |