Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 4/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598651 | 0.83 | TSHR (0.47) | LMNAHPGDCTSSCTSKSMN1; SMN2 | |
| SCHEMBL10614257 | 0.83 | KCNK3 (0.43) | LMNAHPGDCTRB1HPGDSS1PR3 | |
| SCHEMBL11639107 | 0.80 | TSHR (0.44) | LMNAHPGDCTSSCTSKSMN1; SMN2 | |
| SCHEMBL14065364 | 0.80 | ALDH1A1 (0.53) | CTRB1CTSSCTSKALDH1A1 | |
| SCHEMBL10922453 | 0.79 | SMN1; SMN2 (0.46) | LMNAHPGDCTSLCTSSCTSK | |
| SCHEMBL5236032 | 0.79 | HTT (0.51) | HPGDNPC1ALDH1A1RAB9A | |
| SCHEMBL6607452 | 0.78 | LMNA (0.61) | LMNAHPGDCTRB1HPGDSS1PR3 | |
| SCHEMBL11249549 | 0.77 | CTSS (0.48) | LMNAHPGDCTSLCTSSCTSK | |
| SCHEMBL15716728 | 0.77 | CTSS (0.51) | CTSLCTSSCTSKCTSBSMN1; SMN2 | |
| SCHEMBL7723710 | 0.76 | CTSL (0.54) | LMNAHPGDCTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160237074-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC Foundation for Research Development (10 pp.) | 2016-08-18 | — | — | US | disclosed |
| US-20130137728-A1 | Compositions and Methods for the Treatment of Degenerative Diseases | MUSC Foundation for Research and Development (US) | 2013-05-30 | — | — | US | disclosed |
| EP-0432442-A1 | ACAT inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237074-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | PCSK9, ACHE, CLN6 | LMNA 98/4885HPGD 89/4885CTRB1 166/4885 |
| US-20130137728-A1 | Compositions and Methods for the Treatment of Degenerative Diseases | REN, PCSK9, LIPA | LMNA 246/4885HPGD 101/4885CTRB1 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.