Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.47 |
| ▸ | REN | P00797 | 3/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9848617 | 0.83 | BACE1 (0.38) | BACE1RENCTSD | |
| SCHEMBL9848673 | 0.80 | BACE1 (0.53) | BACE1CTSD | |
| SCHEMBL9848705 | 0.75 | BACE1 (0.43) | BACE1RENCTSD | |
| SCHEMBL9848692 | 0.74 | LTA4H (0.54) | — | |
| SCHEMBL9848678 | 0.73 | BACE1 (0.42) | BACE1RENCTSD | |
| SCHEMBL11199973 | 0.72 | CTSS (0.54) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8528279 | 0.72 | PSEN1 (0.57) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL2185519 | 0.71 | CTSC (0.54) | BACE1CTSD | |
| SCHEMBL17456239 | 0.70 | OPRD1 (0.55) | — | |
| SCHEMBL9848649 | 0.69 | BACE1 (0.55) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0438873-A1 | Inhibitor of ribonucleotide reductase of herpes viruses | MERCK & CO. INC. (US) | 1991-07-31 | — | — | EP | disclosed |