Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.83 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.91 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Di(Hydroxyethyl)Ether SCHEMBL3816074 | 1.00 | — | — | |
| Di(Hydroxyethyl)Ether SCHEMBL5174214 | 1.00 | — | — | |
| Triethylene Glycol SCHEMBL31493180 | 0.96 | MEN1 (0.92) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Pentaethylene Glycol SCHEMBL31282309 | 0.96 | MEN1 (0.92) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Pentaethylene Glycol SCHEMBL28986980 | 0.96 | MEN1 (0.92) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Tetraethylene Glycol SCHEMBL7110780 | 0.96 | MEN1 (0.92) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Hexaethylene Glycol SCHEMBL6555741 | 0.96 | MEN1 (0.92) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL8939357 | 0.96 | MEN1 (0.92) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Tetraethylene Glycol SCHEMBL9132284 | 0.96 | MEN1 (0.92) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Tetraethylene Glycol SCHEMBL27473683 | 0.96 | MEN1 (0.92) | TSHRMAPK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106212467-A | A kind of bactericidal composition and application thereof | 山东润博生物科技有限公司 | 2016-12-14 | — | — | CN | claimed |
| CN-110660650-B | Semiconductor device and method for manufacturing the same | 台湾积体电路制造股份有限公司 | 2022-09-13 | — | — | CN | disclosed |
| CN-110660650-A | Semiconductor device and method for manufacturing the same | 台湾积体电路制造股份有限公司 | 2020-01-07 | — | — | CN | disclosed |
| CN-109863148-A | The purposes of fungicide prevention and treatment pomaceous fruit and the brown rot on tone fruit trees before UK-2A | 美国陶氏益农公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-109843060-A | Pyridine amide N-oxide compounds having fungicidal activity | 美国陶氏益农公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-109843064-A | Pyrido-1, 3-oxazin-2, 4-dione compounds with fungicidal activity | 美国陶氏益农公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-109843877-A | The purposes of fungicide prevention and treatment rice blast before UK-2A | 美国陶氏益农公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-109843063-A | Pyrido-1, 3-oxazin-2, 4-dione compounds with fungicidal activity | 美国陶氏益农公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-109843057-A | Pyridine amide N-oxide compounds having fungicidal activity | 美国陶氏益农公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-109843061-A | Thiopyrimidinamide compounds with fungicidal activity | 美国陶氏益农公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-1864484-A | Compound sterilization composition based on kresoxim methyl | ANHUI HUAXING CHEMICAL INDUSTR (CN) | 2006-11-22 | — | — | CN | disclosed |
| CN-1836513-A | Compound insecticidal composition containing fipronil | ANHUI HUAXING CHEMICAL INDUSTR (CN) | 2006-09-27 | — | — | CN | disclosed |
| EP-0461885-A2 | Film for pellicle | Tosoh Corporation (JP) | 1991-12-18 | — | — | EP | disclosed |
| EP-0344909-A2 | Non-aqueous, nonionic heavy duty laundry detergent with improved stability using microspheres and/or vicinalhydroxy compounds | Colgate-Palmolive Company (US) | 1989-12-06 | — | — | EP | disclosed |
| EP-0340989-A2 | Non-aqueous, nonionic heavy duty laundry detergent with improved stability | Colgate-Palmolive Company (US) | 1989-11-08 | — | — | EP | disclosed |
| US-4808692-A | Preparation of advanced epoxy resins from epoxy resins and dihydric phenols in the presence of phosphonium compounds | THE DOW CHEMICAL COMPANY (US) | 1989-02-28 | — | — | US | disclosed |
| US-4567213-A | LOW WATER CONTENT | VIDEOJET SYSTEMS INTERNATIONAL, INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4482731-A | Process for the preparation of trans-3-(z-2-chloro-2-aryl-vinyl)-2,2-dimethyl-cyclopropane-1-carboxylic acid derivatives, and the use of intermediate products in agents for compating pests | BAYER AKTIENGESELLSCHAFT (DE) | 1984-11-13 | — | — | US | disclosed |
| US-4446280-A | ALKYL ACRYLAMIDOGLYCOLATE ETHER POLYMER | AMERICAN CYANAMID COMPANY (US) | 1984-05-01 | — | — | US | disclosed |
| US-4297129-A | HERBICIDES; WILD OATS; NONPHYTOTOXIC | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-10-27 | — | — | US | disclosed |