Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4383031 | 0.87 | EPAS1 (0.44) | PDE7AMEN1KMT2AHPGDMAPT | |
| SCHEMBL4376514 | 0.85 | LMNA (0.42) | PDE7AMEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9853789 | 0.85 | MERTK (0.48) | MEN1KMT2AHPGDSMN1; SMN2LMNA | |
| SCHEMBL7055435 | 0.85 | ALDH1A1 (0.45) | PDE7AMEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL4377981 | 0.85 | MEN1 (0.48) | MEN1KMT2AHPGDSMN1; SMN2LMNA | |
| SCHEMBL4381239 | 0.83 | MEN1 (0.51) | PDE7AMEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9853822 | 0.82 | MAPT (0.46) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL9853579 | 0.79 | PIN1 (0.47) | MEN1KMT2AHPGDSMN1; SMN2LMNA | |
| SCHEMBL11547238 | 0.78 | HPGD (0.68) | MEN1KMT2AHPGDSMN1; SMN2LMNA | |
| SCHEMBL9853587 | 0.77 | ALDH1A1 (0.37) | PDE7AMEN1KMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432684-B1 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | UNIV LIEGE (BE) | 2009-03-25 | — | — | EP | disclosed |
| US-20070173534-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITE DE LIEGE | 2007-07-26 | — | — | US | disclosed |
| US-7226936-B2 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITY DE LIEGE (BE) | 2007-06-05 | — | — | US | disclosed |
| US-20050020642-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITE DE LIEGE (BE) | 2005-01-27 | — | — | US | disclosed |
| EP-1432684-A2 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | University of Liege (BE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029217-A2 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | UNIVERSITE DE LIEGE (BE) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173534-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | PTGIS, ARSA, C3AR1 | PDE7A 1809/4885MEN1 1648/4885KMT2A 2899/4885 |
| US-20050020642-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | ARSA, PTGIS, C3AR1 | PDE7A 2413/4885MEN1 1884/4885KMT2A 2779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.