Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853587 | 0.87 | ALDH1A1 (0.37) | PIN1SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL4377981 | 0.84 | MEN1 (0.48) | PIN1SMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL8486512 | 0.81 | PIN1 (0.55) | PIN1SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL4381239 | 0.80 | MEN1 (0.51) | SMN1; SMN2LMNAMAPTALDH1A1F10 | |
| SCHEMBL4376514 | 0.79 | LMNA (0.42) | SMN1; SMN2LMNAMAPTHTTALDH1A1 | |
| SCHEMBL9853789 | 0.79 | MERTK (0.48) | SMN1; SMN2LMNAMAPTHTTALDH1A1 | |
| SCHEMBL4375480 | 0.79 | PDE7A (0.49) | SMN1; SMN2LMNAMAPTALDH1A1GPR84 | |
| SCHEMBL7055435 | 0.79 | ALDH1A1 (0.45) | SMN1; SMN2LMNAMAPTHTTALDH1A1 | |
| SCHEMBL9853588 | 0.78 | PIN1 (0.49) | PIN1LMNAMAPTHTTALDH1A1 | |
| SCHEMBL9390091 | 0.78 | HPGD (0.54) | PIN1SMN1; SMN2LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | claimed |
| EP-0405426-A2 | Naphthylamino- and naphthyloxy-pyridinamines and related compounds, a process for their preparation and their use as dermatological agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | disclosed |