Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4383031 | 0.88 | EPAS1 (0.44) | MEN1KMT2AMAPTEPAS1PDE7A | |
| SCHEMBL4375480 | 0.83 | PDE7A (0.49) | MEN1KMT2AMAPTTBXA2RPDE7A | |
| SCHEMBL4377981 | 0.83 | MEN1 (0.48) | MEN1KMT2AMAPTTBXA2RALDH1A1 | |
| SCHEMBL14744331 | 0.80 | MEN1 (0.61) | MEN1KMT2AMAPTEPAS1TBXA2R | |
| SCHEMBL9853579 | 0.80 | PIN1 (0.47) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL11547238 | 0.77 | HPGD (0.68) | MEN1KMT2AMAPTTBXA2RALDH1A1 | |
| SCHEMBL9853587 | 0.75 | ALDH1A1 (0.37) | MEN1KMT2AMAPTTBXA2RPDE7A | |
| SCHEMBL9853789 | 0.75 | MERTK (0.48) | MEN1KMT2AMAPTTBXA2RALDH1A1 | |
| SCHEMBL4376514 | 0.75 | LMNA (0.42) | MEN1KMT2AMAPTTBXA2RPDE7A | |
| SCHEMBL7055435 | 0.75 | ALDH1A1 (0.45) | MEN1KMT2AMAPTTBXA2RPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432684-B1 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | UNIV LIEGE (BE) | 2009-03-25 | — | — | EP | disclosed |
| US-20070173534-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITE DE LIEGE | 2007-07-26 | — | — | US | disclosed |
| US-7226936-B2 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITY DE LIEGE (BE) | 2007-06-05 | — | — | US | disclosed |
| US-20050020642-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITE DE LIEGE (BE) | 2005-01-27 | — | — | US | disclosed |
| EP-1432684-A2 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | University of Liege (BE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029217-A2 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | UNIVERSITE DE LIEGE (BE) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173534-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | PTGIS, ARSA, C3AR1 | MEN1 1648/4885KMT2A 2899/4885MAPT 4060/4885 |
| US-20050020642-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | ARSA, PTGIS, C3AR1 | MEN1 1884/4885KMT2A 2779/4885MAPT 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.