Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853604 | 0.86 | LMNA (0.54) | L3MBTL1ALDH1A1TDP1GPR84MAPT | |
| SCHEMBL2885107 | 0.83 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1TDP1MAPTHPGD | |
| SCHEMBL9853588 | 0.83 | PIN1 (0.49) | L3MBTL1ALDH1A1TDP1GPR84MAPT | |
| SCHEMBL9853789 | 0.78 | MERTK (0.48) | L3MBTL1ALDH1A1TDP1MAPTHPGD | |
| SCHEMBL2556917 | 0.78 | ALDH1A1 (0.54) | L3MBTL1ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL4377981 | 0.77 | MEN1 (0.48) | L3MBTL1ALDH1A1TDP1MAPTHPGD | |
| SCHEMBL11547238 | 0.77 | HPGD (0.68) | L3MBTL1ALDH1A1TDP1MAPTHPGD | |
| SCHEMBL589908 | 0.75 | ALDH1A1 (0.61) | L3MBTL1ALDH1A1TDP1MAPTLMNA | |
| SCHEMBL9853579 | 0.75 | PIN1 (0.47) | L3MBTL1ALDH1A1TDP1GPR84MAPT | |
| SCHEMBL7055435 | 0.72 | ALDH1A1 (0.45) | ALDH1A1TDP1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | claimed |
| EP-0405426-A2 | Naphthylamino- and naphthyloxy-pyridinamines and related compounds, a process for their preparation and their use as dermatological agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | disclosed |