Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.46 |
| ▸ | FEN1 | P39748 | 8/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879473 | 0.85 | TDP1 (0.42) | SLC6A2SLC6A4SLC6A3HTR1APTGER4 | |
| SCHEMBL8976466 | 0.80 | PTGER4 (0.51) | HTR1APTGER4PTGER3PTGER2BCHE | |
| SCHEMBL8732326 | 0.79 | PTGER4 (0.42) | SLC6A2SLC6A3HTR1APTGER4PTGER3 | |
| SCHEMBL8732315 | 0.79 | PTGER4 (0.42) | SLC6A2SLC6A3HTR1APTGER4PTGER3 | |
| SCHEMBL9857824 | 0.79 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1AALOX5AP | |
| SCHEMBL9857122 | 0.75 | HTR1A (0.51) | SLC6A2SLC6A4SLC6A3HTR1AALOX5AP | |
| SCHEMBL9857676 | 0.73 | HTR1A (0.52) | SLC6A2SLC6A4SLC6A3HTR1AALOX5AP | |
| SCHEMBL12670343 | 0.73 | L3MBTL1 (0.36) | HTR1AMAOBMEN1KMT2A | |
| SCHEMBL9858085 | 0.73 | PTPN5 (0.34) | SLC6A2SLC6A4SLC6A3ALOX5APFEN1 | |
| SCHEMBL5879437 | 0.72 | LMNA (0.40) | PTGER4PTGER3PTGER2KDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0301402-B1 | LEUKOTRIENE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF ILLNESSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-21 | — | — | EP | disclosed |
| US-4855323-A | Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-08 | — | — | US | disclosed |
| EP-0301402-A1 | Leukotriene antagonists, process for their preparation and their use in the treatment of illnesses | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-01 | — | — | EP | disclosed |