Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 4/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 3/20 | 0.32 |
| ▸ | CEL | P19835 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5437476 | 0.81 | GABRA1 (0.43) | — | |
| SCHEMBL11598412 | 0.80 | PTPN5 (0.39) | PTPN5PTPN2NAAAPTGDR2FEN1 | |
| SCHEMBL4058553 | 0.78 | PTGDR2 (0.41) | PTPN5PTPN2NAAAPTGDR2FEN1 | |
| SCHEMBL8022072 | 0.77 | GABRA1 (0.55) | PTPN5PTPN2NAAAPTGDR2HDAC4 | |
| SCHEMBL2916746 | 0.76 | GABRA1 (0.53) | PTPN5PTPN2NAAAPTGDR2FEN1 | |
| SCHEMBL1385528 | 0.76 | PTGDR2 (0.39) | PTPN5PTPN2NAAAPTGDR2FEN1 | |
| SCHEMBL10772495 | 0.76 | GABRA1 (0.53) | PTPN5PTPN2NAAAPTGDR2FEN1 | |
| SCHEMBL4960831 | 0.75 | PTPN5 (0.44) | PTPN5PTPN2PTGDR2FEN1CEL | |
| SCHEMBL8976185 | 0.75 | ALDH1A1 (0.46) | — | |
| SCHEMBL5795157 | 0.73 | CA2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0301402-B1 | LEUKOTRIENE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF ILLNESSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-21 | — | — | EP | disclosed |
| US-4855323-A | Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-08 | — | — | US | disclosed |
| EP-0301402-A1 | Leukotriene antagonists, process for their preparation and their use in the treatment of illnesses | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-01 | — | — | EP | disclosed |