Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 8/20 | 0.48 |
| ▸ | PYGM | P11217 | 8/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865957 | 0.93 | PYGL (0.44) | PYGLPYGMALOX12CYP3A4CYP2C9 | |
| SCHEMBL9867642 | 0.90 | PYGL (0.46) | PYGLPYGMALOX12CYP3A4CYP2C9 | |
| SCHEMBL30157261 | 0.89 | PYGM (0.62) | PYGLPYGM | |
| SCHEMBL4072118 | 0.89 | PYGM (0.62) | PYGLPYGM | |
| SCHEMBL10659301 | 0.89 | PYGL (0.52) | PYGLPYGMALDH1A1 | |
| SCHEMBL9865950 | 0.88 | PYGM (0.52) | PYGLPYGM | |
| SCHEMBL10649530 | 0.85 | PYGL (0.39) | PYGLPYGMALOX12CYP3A4CYP2C9 | |
| SCHEMBL11007467 | 0.85 | ALDH1A1 (0.46) | ALDH1A1KDM4EACHECACNA1FCACNA1D | |
| SCHEMBL11012203 | 0.82 | ALDH1A1 (0.41) | PYGLPYGMCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9865258 | 0.82 | CYP3A4 (0.47) | PYGLPYGMALOX12CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026714-A | Novel 1-alkyl-substituted 1,4-dihydropyridinelactone anti-diabetics | BAYER AKTIENGESELLSCHAFT (DE) | 1991-06-25 | — | — | US | claimed |
| US-5026714-A | Novel 1-alkyl-substituted 1,4-dihydropyridinelactone anti-diabetics | BAYER AKTIENGESELLSCHAFT (DE) | 1991-06-25 | — | — | US | disclosed |