SCHEMBL4072118

SCHEMBL4072118

CCN1C(C)=C(C(=O)OC(C)C)C(c2ccccc2Cl)C2=C1COC2=O

nearest known ligand 0.62

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PYGM P11217 19/20 0.62
PYGL P06737 18/20 0.62
ALOX15 P16050 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30157261 1.00 PYGM (0.62) PYGMPYGLALOX15
SCHEMBL9865950 0.91 PYGM (0.52) PYGMPYGL
SCHEMBL9864934 0.90 PYGM (0.49) PYGMPYGL
SCHEMBL9865516 0.89 PYGL (0.48) PYGMPYGL
SCHEMBL9867642 0.87 PYGL (0.46) PYGMPYGL
SCHEMBL9865794 0.86 PYGM (0.46) PYGMPYGL
SCHEMBL10425160 0.86 PYGM (0.46) PYGMPYGLALOX15
SCHEMBL9829022 0.86 PYGL (0.48) PYGMPYGLALOX15
SCHEMBL10659301 0.86 PYGL (0.52) PYGMPYGL
SCHEMBL9865957 0.84 PYGL (0.44) PYGMPYGL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260053761-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER UNIV OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2026-02-26 US claimed
US-20230255974-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE 2023-08-17 US claimed
US-5026714-A Novel 1-alkyl-substituted 1,4-dihydropyridinelactone anti-diabetics BAYER AKTIENGESELLSCHAFT (DE) 1991-06-25 US claimed
EP-0158138-B1 1-ALKYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE LACTONES, METHOD FOR THEIR PREPARATION AND THEIR USE IN MEDICINES BAYER AG (DE) 1988-10-12 EP claimed
US-20260053761-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER UNIV OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2026-02-26 US disclosed
US-20230255974-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE 2023-08-17 US disclosed
WO-2009048746-A2 SELF-TANNING COSMETIC COMPOSITIONS AND METHODS ELC MANAGEMENT LLC (US) 2009-04-16 WO disclosed
US-20090092566-A1 SELF-TANNING COSMETIC COMPOSITIONS AND METHODS ELC MANAGEMENT LLC 2009-04-09 US disclosed
US-4786641-A HYPOGLYCEMIC AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1988-11-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260053761-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER THRA, THRB, TRHR PYGM 1715/4885PYGL 1869/4885ALOX15 453/4885
US-20090092566-A1 SELF-TANNING COSMETIC COMPOSITIONS AND METHODS TNNI3K, CHEK1, CHEK2 PYGM 1576/4885PYGL 3074/4885ALOX15 3456/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.