Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865443 | 0.89 | MAPT (0.43) | HTR1AHTR2AHTR2CDRD4HTR7 | |
| SCHEMBL9868353 | 0.85 | SLC11A2 (0.49) | HTR1AHTR2AHTR2CMEN1KMT2A | |
| SCHEMBL9865351 | 0.83 | HTR1A (0.53) | HTR1AHTR2AHTR2CDRD4HTR7 | |
| Hydrochloric Acid SCHEMBL10445024 | 0.82 | HTR1A (0.51) | HTR1AHTR2AHTR2CDRD4HTR7 | |
| Hydrochloric Acid SCHEMBL10445023 | 0.82 | HTR1A (0.51) | HTR1AHTR2AHTR2CDRD4HTR7 | |
| SCHEMBL9879719 | 0.79 | ACHE (0.43) | HRH3ACHETHRATHRBMEN1 | |
| SCHEMBL9867723 | 0.79 | CD274 (0.43) | ACHEPDCD1CD274BCHE | |
| SCHEMBL9601994 | 0.75 | ACHE (0.40) | HTR1AHTR2AHTR7DRD3HRH3 | |
| SCHEMBL9601499 | 0.75 | ACHE (0.41) | HTR1AHTR2AHTR7DRD3HRH3 | |
| SCHEMBL9866167 | 0.73 | ACHE (0.40) | HTR1AHTR2AHTR2CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |