Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867836 | 0.88 | SIRT1 (0.46) | MAPK1HSD17B10KDM4ELMNAPKM | |
| SCHEMBL9866780 | 0.82 | ALOX5 (0.55) | HSD17B10KDM4ELMNAHPGDUSP2 | |
| SCHEMBL9867950 | 0.78 | NPC1 (0.38) | KDM4EHPGDPOLBTNFRSF1AALOX5 | |
| SCHEMBL9866482 | 0.76 | LMNA (0.50) | MAPK1HSD17B10KDM4ELMNAPKM | |
| SCHEMBL9867508 | 0.75 | NPC1 (0.45) | HSD17B10KDM4EHPGDGAAMAPT | |
| SCHEMBL9868331 | 0.75 | CYP2C9 (0.44) | HSD17B10KDM4ELMNAGAAMAPT | |
| SCHEMBL10868061 | 0.73 | TNFRSF1A (0.46) | MAPK1HSD17B10KDM4ELMNAHPGD | |
| SCHEMBL8420546 | 0.73 | TNFRSF1A (0.48) | MAPK1HSD17B10KDM4ELMNAHPGD | |
| SCHEMBL4113584 | 0.72 | GLRA3 (0.54) | MAPK1HSD17B10KDM4ELMNAUSP2 | |
| SCHEMBL11211507 | 0.72 | BCL2 (0.47) | MAPK1HSD17B10KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | claimed |
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |