Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.36 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.36 |
| ▸ | GLRB | P48167 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868574 | 0.90 | MCL1 (0.39) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL9867508 | 0.87 | NPC1 (0.45) | NPC1RAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL9869017 | 0.84 | ALOX5 (0.52) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9868498 | 0.81 | GLRA3 (0.49) | L3MBTL1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL9867089 | 0.78 | MAPK1 (0.41) | RAB9AL3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL9867051 | 0.76 | RAB9A (0.41) | NPC1RAB9AL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL4113584 | 0.76 | GLRA3 (0.54) | MEN1KMT2AALDH1A1KDM4EMCL1 | |
| SCHEMBL10868061 | 0.74 | TNFRSF1A (0.46) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL9866663 | 0.71 | ALOX5 (0.47) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL9869198 | 0.71 | EDNRA (0.47) | NPC1RAB9AL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |