Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NMT2 | O60551 | 6/20 | 0.39 |
| ▸ | NMT1 | P30419 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867051 | 0.90 | RAB9A (0.41) | NPC1RAB9AMAPTKDM4EHSD17B10 | |
| SCHEMBL9867950 | 0.87 | NPC1 (0.38) | NPC1RAB9AKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL9866663 | 0.85 | ALOX5 (0.47) | NPC1RAB9AMAPTKDM4EHSD17B10 | |
| SCHEMBL9867487 | 0.82 | RAB9A (0.48) | NPC1RAB9AMAPTKDM4EHSD17B10 | |
| SCHEMBL9868574 | 0.78 | MCL1 (0.39) | NPC1RAB9AMAPTKDM4EL3MBTL1 | |
| SCHEMBL9867505 | 0.77 | SMN1; SMN2 (0.50) | NPC1RAB9AMAPTKDM4EHSD17B10 | |
| SCHEMBL9867089 | 0.75 | MAPK1 (0.41) | RAB9AMAPTKDM4EHSD17B10L3MBTL1 | |
| SCHEMBL9868567 | 0.74 | RAB9A (0.59) | NPC1RAB9AMAPTKDM4EHSD17B10 | |
| SCHEMBL9866325 | 0.73 | RAB9A (0.58) | NPC1RAB9AMAPTKDM4EHSD17B10 | |
| SCHEMBL9869017 | 0.72 | ALOX5 (0.52) | NPC1RAB9AMAPTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |