Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.39 |
| ▸ | GLRB | P48167 | 1/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | HPN | P05981 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2269577 | 0.75 | ALDH1A1 (0.37) | CYP2C9CYP2C19CYP1A2SMN1; SMN2CA2 | |
| SCHEMBL9866780 | 0.75 | ALOX5 (0.55) | ALDH1A1MAPTALOX15HSD17B10KDM4E | |
| SCHEMBL9867089 | 0.75 | MAPK1 (0.41) | SMN1; SMN2ALDH1A1POLBMAPTALOX15 | |
| SCHEMBL9867836 | 0.73 | SIRT1 (0.46) | CYP2C9CYP2C19CYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2268415 | 0.71 | GABRA1 (0.44) | CYP2C9CYP2C19CYP1A2SMN1; SMN2CA2 | |
| SCHEMBL16649211 | 0.71 | ALDH1A1 (0.37) | CYP2C9CYP2C19CYP1A2SMN1; SMN2CA2 | |
| SCHEMBL9244593 | 0.67 | SMN1; SMN2 (0.64) | CYP2C9CYP2C19CYP1A2SMN1; SMN2CA2 | |
| SCHEMBL20657093 | 0.66 | CA2 (0.65) | CYP2C9CYP2C19CYP1A2SMN1; SMN2CA2 | |
| SCHEMBL9868498 | 0.66 | GLRA3 (0.49) | CYP2C9CYP2C19CYP1A2SMN1; SMN2CA2 | |
| SCHEMBL29462687 | 0.64 | CA2 (0.62) | CYP2C9CYP2C19CYP1A2SMN1; SMN2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |