SCHEMBL9871252

SCHEMBL9871252

CCN1C(=S)NC(C)=C(C(=O)O)C1c1ccc(Cl)c([N+](=O)[O-])c1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 14/20 0.47
CACNA1D Q01668 14/20 0.47
CACNA1S Q13698 14/20 0.47
CACNA1C Q13936 14/20 0.47
ALDH1A1 P00352 2/20 0.47
LMNA P02545 2/20 0.47
MAPT P10636 2/20 0.47
ALOX12 P18054 1/20 0.47
DHFR P00374 1/20 0.41
KMT2A Q03164 1/20 0.40
NPSR1 Q6W5P4 1/20 0.39
ADRA2A P08913 1/20 0.39
ADRA2B P18089 1/20 0.39
ADRA2C P18825 1/20 0.39
ADRA1D P25100 1/20 0.39
ADRA1A P35348 1/20 0.39
ADRA1B P35368 1/20 0.39
VCAM1 P19320 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9869659 0.86 CACNA1F (0.45) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL9869503 0.86 CACNA1F (0.44) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL9869835 0.81 CACNA1F (0.68) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL9871923 0.76 ALDH1A1 (0.54) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL9870085 0.76 GUSB (0.44) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL9871999 0.74 ALDH1A1 (0.47) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL4056646 0.72 LMNA (0.53) ALDH1A1LMNAMAPTALOX12KMT2A
SCHEMBL9869833 0.71 CACNA1F (0.42) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL10358732 0.71 CACNA1D (0.58) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL9475596 0.70 CACNA1C (0.68) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5071849-A Antiinflammatory, antianginal agent EGIS GYOGYSZERGYAR (HU) 1991-12-10 US disclosed