Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865031 | 0.85 | RAB9A (0.40) | HSD11B1GPBAR1MEN1KMT2APDE4D | |
| SCHEMBL1086256 | 0.78 | NPC1 (0.45) | GPBAR1PTGS1MEN1KMT2AL3MBTL1 | |
| SCHEMBL9936299 | 0.76 | HSD11B1 (0.36) | HSD11B1GPBAR1PTGS1PTGS2 | |
| SCHEMBL3940018 | 0.74 | NR1H4 (0.42) | GPBAR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4970805 | 0.73 | CYP17A1 (0.37) | MEN1KMT2AGABRA5 | |
| SCHEMBL11593511 | 0.72 | PTGS1 (0.51) | GPBAR1PTGS1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1086652 | 0.71 | PTGS1 (0.47) | HSD11B1GPBAR1PTGS1KMT2ASMN1; SMN2 | |
| SCHEMBL1679666 | 0.70 | LMNA (0.44) | GPBAR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6004541 | 0.67 | PTGS2 (0.39) | GPBAR1PTGS1KMT2ASMN1; SMN2PTGS2 | |
| SCHEMBL6126814 | 0.67 | CNR1 (0.34) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011938-A | Antimicrobials | ELI LILLY AND COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| US-4940718-A | BACTERICIDES | ELI LILLY AND COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0202046-A1 | 7-Substituted bicyclic pyrazolidinones | ELI LILLY AND COMPANY (US) | 1986-11-20 | — | — | EP | disclosed |