Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20993362 | 1.00 | DDB1 (0.37) | DDB1CRBNALDH1A1MAPTNPC1 | |
| SCHEMBL20993216 | 1.00 | DDB1 (0.37) | DDB1CRBNALDH1A1MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL6965524 | 0.98 | DDB1 (0.36) | DDB1CRBNALDH1A1MAPTNPC1 | |
| SCHEMBL27031073 | 0.84 | DDB1 (0.40) | DDB1CRBNALDH1A1MAPTNPC1 | |
| SCHEMBL13928045 | 0.79 | DDB1 (0.36) | DDB1CRBNALDH1A1MAPTNPC1 | |
| SCHEMBL5654826 | 0.78 | ALDH1A1 (0.38) | DDB1CRBNALDH1A1MAPTNPC1 | |
| SCHEMBL5655543 | 0.78 | ALDH1A1 (0.35) | DDB1CRBNALDH1A1MAPTNPC1 | |
| SCHEMBL11562353 | 0.77 | CHRNB2 (0.46) | DDB1CRBNALDH1A1MAPTNPC1 | |
| SCHEMBL231126 | 0.77 | PARP1 (0.35) | ALDH1A1KMT2AKDM4ECYP1A2POLB | |
| SCHEMBL3926825 | 0.76 | CHRNB2 (0.50) | DDB1CRBNALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024103023-A2 | 12-LIPOXYGENASE INHIBITORS FOR THE TREATMENT OF LUPUS | VERALOX THERAPEUTICS (US) | 2024-05-16 | — | — | WO | claimed |
| WO-2024097846-A1 | ORAL PHARMACEUTICAL FORMULATIONS CONTAINING 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES | VERALOX THERAPEUTICS (US) | 2024-05-10 | — | — | WO | claimed |
| WO-2024019959-A1 | COMPOSITIONS FOR MODULATING LIPOXYGENASE AND METHODS OF USING SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-01-25 | — | — | WO | claimed |
| EP-3054936-B1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2023-10-18 | — | — | EP | claimed |
| US-20200392077-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-12-17 | — | — | US | claimed |
| US-10752581-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2020-08-25 | — | — | US | claimed |
| CN-108341807-B | Piperazine amide compound containing benzodioxane skeleton and preparation method and application thereof | 平顶山学院 | 2020-07-28 | — | — | CN | claimed |
| US-20190276395-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-09-12 | — | — | US | claimed |
| US-10266488-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2019-04-23 | — | — | US | claimed |
| CN-107441100-A | Treat the compound of ischemical reperfusion injury | 武汉大学 | 2017-12-08 | — | — | CN | claimed |
| US-8309726-B2 | Substituted piperazine compounds of formula 8 | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-11-13 | — | — | US | claimed |
| US-20120270882-A1 | FLUORINATED DERIVATES OF 3-HYDROXYPYRIDIN-4-ONES | APOTEX TECHNOLOGIES INC. (CA) | 2012-10-25 | — | — | US | claimed |
| EP-2448922-A1 | FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES | Apotex Technologies Inc. (CA) | 2012-05-09 | — | — | EP | claimed |
| EP-2150527-B1 | ANTHRANILIC ACID DERIVATIVE AS ANTICANCER AGENT AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2011-01-19 | — | — | EP | claimed |
| WO-2011000104-A1 | FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES | APOTEX TECHNOLOGIES INC. (CA) | 2011-01-06 | — | — | WO | claimed |
| EP-0693505-B1 | Elastomers and products having reduced hysteresis and process for the preparation thereof | BRIDGESTONE CORP (JP) | 1999-05-06 | — | — | EP | claimed |
| EP-0693505-A1 | Elastomers and products having reduced hysteresis and process for the preparation thereof | BRIDGESTONE CORPORATION (JP) | 1996-01-24 | — | — | EP | claimed |
| US-5210193-A | Bactericide | AMERICAN CYANAMID COMPANY (US) | 1993-05-11 | — | — | US | claimed |
| US-4868299-A | Antibacterially active pyrido-benzothiazine derivatives with long-term action | MEDIOLANUM FARMACEUTICI SRL (IT) | 1989-09-19 | — | — | US | claimed |
| EP-0230053-A2 | 7-(Substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1987-07-29 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266488-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | ALOX12, ALOX15, ALOX15B | DDB1 2758/4885CRBN 3690/4885ALDH1A1 3051/4885 |
| US-20200392077-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | ALOX12, ALOX15, ALOX15B | DDB1 2758/4885CRBN 3690/4885ALDH1A1 3051/4885 |
| US-20190276395-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | ALOX12, ALOX15, ALOX15B | DDB1 2758/4885CRBN 3690/4885ALDH1A1 3051/4885 |
| US-20120270882-A1 | FLUORINATED DERIVATES OF 3-HYDROXYPYRIDIN-4-ONES | FH, FECH, FTH1 | DDB1 1648/4885CRBN 3464/4885ALDH1A1 209/4885 |
| US-10752581-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | ALOX12, ALOX15, ALOX15B | DDB1 2758/4885CRBN 3690/4885ALDH1A1 3051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.