SCHEMBL989695

SCHEMBL989695

O=C(O)c1cc2ccccc2c(-c2c(O)c(C(=O)O)cc3ccccc23)c1O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.67
GPR35 Q9HC97 2/20 0.67
CYP2D6 P10635 1/20 0.63
WDR5 P61964 1/20 0.58
MEN1 O00255 5/20 0.58
KMT2A Q03164 5/20 0.58
HPGD P15428 3/20 0.58
HSD17B10 Q99714 3/20 0.58
MAPT P10636 3/20 0.58
KDM4E B2RXH2 3/20 0.58
ALDH1A1 P00352 3/20 0.58
PKM P14618 1/20 0.58
HTT P42858 1/20 0.58
LDHA P00338 1/20 0.56
THRB P10828 1/20 0.56
CYP2C9 P11712 1/20 0.56
TSHR P16473 1/20 0.56
ALOX12 P18054 1/20 0.56
ATIC P31939 1/20 0.56
ME2 P23368 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11067214 0.91 POLB (0.61) POLBGPR35CYP2D6WDR5MEN1
SCHEMBL8057702 0.90 MEN1 (0.70) POLBGPR35CYP2D6WDR5MEN1
SCHEMBL8463472 0.90 POLB (0.56) POLBGPR35CYP2D6WDR5MEN1
SCHEMBL24891573 0.90 POLB (0.59) POLBGPR35CYP2D6WDR5MEN1
SCHEMBL6349823 0.87 POLB (0.54) POLBGPR35CYP2D6WDR5MEN1
SCHEMBL28464804 0.87 MEN1 (0.75) POLBGPR35CYP2D6WDR5MEN1
SCHEMBL3391301 0.86 POLB (0.69) POLBGPR35CYP2D6WDR5MEN1
SCHEMBL9254751 0.85 HNF4A (0.58) POLBGPR35CYP2D6WDR5MEN1
SCHEMBL9938080 0.85 GPR35 (0.62) POLBGPR35CYP2D6WDR5MEN1
SCHEMBL5380957 0.83 ME2 (0.70) POLBGPR35CYP2D6MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114409885-B Low-extraction motor film and preparation method thereof 宁波勤邦新材料科技有限公司 2023-06-02 CN claimed
CN-114409885-A Low-extraction motor film and preparation method thereof 宁波勤邦新材料科技有限公司 2022-04-29 CN claimed
CN-111686798-A BINOL axis chiral thiourea organic catalyst for preparing spiro tetrahydrothiophene 秦婷 2020-09-22 CN claimed
US-9622995-B2 Treatment of disorders associated with G protein-coupled receptor 35 (GPR35) Temple University—Of the Commonwealth System of Higher Education (US) 2017-04-18 US claimed
US-20150265561-A1 TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) NATIONAL INSTITUTES OF HEALTH 2015-09-24 US claimed
US-9040583-B2 Treatment of disorders associated with G protein-coupled receptor 35 (GPR35) TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2015-05-26 US claimed
US-20120122987-A1 TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2012-05-17 US claimed
WO-2011011235-A1 TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2011-01-27 WO claimed
EP-1430950-B1 Hydroformylation of unsaturated compounds using polymeric phosphite ligands INVISTA TECH SARL (US) 2006-02-22 EP claimed
EP-1225978-B1 HYDROFORMYLATION OF UNSATURATED COMPOUNDS USING POLYMERIC PHOSPHITE LIGANDS INVISTA TECH SARL (US) 2005-03-16 EP claimed
JP-2003533337-A 2003-11-11 JP claimed
US-20020177737-A1 Hydroformylation of unsaturated compounds using polymeric phosphite ligands INVISTA NORTH AMERICA S.A.R.L. 2002-11-28 US claimed
EP-1225978-A1 HYDROFORMYLATION OF UNSATURATED COMPOUNDS USING POLYMERIC PHOSPHITE LIGANDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2002-07-31 EP claimed
US-6420611-B1 GROUP 8 METAL WITH PHOSPHITE POLYMERS FROM POLYHYDRIC ALCOHOL, AMINE AND PHOSPHOCHLOROIDITE E. I. DU PONT DE NEMOURS AND COMPANY 2002-07-16 US claimed
EP-1216268-A1 POLYMERIC PHOSPHITE COMPOSITION AND HYDROCYANATION OF UNSATURATED ORGANIC COMPOUNDS AND THE ISOMERIZATION OF UNSATURATED NITRILES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2002-06-26 EP claimed
US-20010049431-A1 Polymeric phosphite composition and hydrocyanation of unsaturated organic compounds and the isomerization of unsaturated nitriles INVISTA NORTH AMERICA S.A.R.L. 2001-12-06 US claimed
US-6284865-B1 POLYESTER OR POLYAMIDE CONTAINING PHOSPHITE GROUPS PREPARED FROM AN AROMATIC DIHYDROXYPOLYCARBOXYLIC ACID, A POLYOL OR DIAMINE AND A PHOSPHOROCHLORIDITE E. I. DU PONT DE NEMOURS AND COMPANY 2001-09-04 US claimed
WO-2001021308-A1 HYDROFORMYLATION OF UNSATURATED COMPOUNDS USING POLYMERIC PHOSPHITE LIGANDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2001-03-29 WO claimed
WO-2001021684-A1 POLYMERIC PHOSPHITE COMPOSITION AND HYDROCYANATION OF UNSATURATED ORGANIC COMPOUNDS AND THE ISOMERIZATION OF UNSATURATED NITRILES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2001-03-29 WO claimed
US-4224221-A Modifier composition for azo pigments based on 2-hydroxy-3-naphthoic acid AMERICAN CYANAMID COMPANY (US) 1980-09-23 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020177737-A1 Hydroformylation of unsaturated compounds using polymeric phosphite ligands PHOSPHO1, PPIP5K2, PF4 POLB 1285/4885GPR35 3342/4885CYP2D6 3542/4885
US-20120122987-A1 TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) GPR35, GPR68, GRM5 POLB 4617/4885GPR35 1/4885CYP2D6 4196/4885
US-20150265561-A1 TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) GPR35, GPR68, GRM5 POLB 4617/4885GPR35 1/4885CYP2D6 4196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.