Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536587 | 0.95 | ALOX15 (0.36) | ALOX15MAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL4455864 | 0.95 | ALOX15 (0.42) | ALOX15MAPTKDM4EALDH1A1MAPK1 | |
| Water SCHEMBL9983319 | 0.92 | MAPT (0.40) | ALOX15MAPTKDM4EALDH1A1MAPK1 | |
| Potassium Ion SCHEMBL366682 | 0.89 | ALDH1A1 (0.42) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| Water SCHEMBL4269781 | 0.87 | ALDH1A1 (0.41) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| Sulfuric Acid SCHEMBL5248436 | 0.87 | ALDH1A1 (0.41) | MAPTKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL5447715 | 0.84 | KDM4E (0.34) | ALOX15MAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL14894927 | 0.84 | ALDH1A1 (0.42) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL3365753 | 0.84 | ALDH1A1 (0.42) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| Potassium Ion SCHEMBL190393 | 0.84 | KMT2A (0.50) | KDM4EALDH1A1MAPK1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230383341-A1 | GENE PROMOTERS FOR USE IN PROKARYOTIC CELLS | EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY (US) | 2023-11-30 | — | — | US | disclosed |
| US-20200277649-A1 | BROAD SPECTRUM DETECTION OF DNA DAMAGE BY REPAIR ASSISTED DAMAGE DETECTION (RADD) | RAMOT AT TEL AVIV UNIVERSITY, LTD (IL) | 2020-09-03 | — | — | US | disclosed |
| WO-2019051043-A1 | BROAD SPECTRUM DETECTION OF DNA DAMAGE BY REPAIR ASSISTED DAMAGE DETECTION (RADD) | UNIVERSITY OF SOUTH ALABAMA (US) | 2019-03-14 | — | — | WO | disclosed |
| EP-2648675-A1 | HAIR RELAXING AND STRAIGHTENING COMPOSITIONS | International Flora Technologies, Ltd. (US) | 2013-10-16 | — | — | EP | disclosed |
| US-20120148517-A1 | Hair Relaxing and Straightening Compositions | INTERNATIONAL FLORA TECHNOLOGIES, LTD. (US) | 2012-06-14 | — | — | US | disclosed |
| WO-2012078658-A1 | HAIR RELAXING AND STRAIGHTENING COMPOSITIONS | INTERNATIONAL FLORA TECHNOLOGIES, LTD. (US) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120148517-A1 | Hair Relaxing and Straightening Compositions | PDE6G, SHH, DNMT3L | ALOX15 3708/4885MAPT 1359/4885KDM4E 666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.