Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15303017 | 0.85 | PTGS2 (0.38) | PTGS2RAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL9905617 | 0.84 | PTGS2 (0.43) | PTGS2RAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL13721386 | 0.79 | GAA (0.56) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL13720494 | 0.75 | GAA (0.51) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL18581856 | 0.72 | MTNR1B (0.60) | RAF1PDK1PDK2PDK3PDK4 | |
| SCHEMBL9900752 | 0.69 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1GAAPOLB | |
| SCHEMBL9924093 | 0.68 | KIT (0.45) | PTGS2RAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL29438018 | 0.68 | KIT (0.45) | PTGS2RAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL13721575 | 0.68 | PKM (0.40) | MEN1KMT2AALDH1A1GAAPOLB | |
| SCHEMBL15303500 | 0.66 | MET (0.38) | PTGS2RAF1MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |