Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 4/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901491 | 0.84 | PTGS2 (0.42) | PTGS2MEN1KMT2ARAF1MAPK14 | |
| SCHEMBL9924093 | 0.83 | KIT (0.45) | PTGS2MEN1KMT2ARAF1S1PR4 | |
| SCHEMBL29438018 | 0.83 | KIT (0.45) | PTGS2MEN1KMT2ARAF1S1PR4 | |
| SCHEMBL1979542 | 0.77 | GAA (0.59) | MEN1KMT2AS1PR4S1PR1S1PR3 | |
| SCHEMBL9900752 | 0.76 | ALDH1A1 (0.41) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL29437992 | 0.68 | KIT (0.39) | PTGS2MEN1KMT2ARAF1MAPK14 | |
| SCHEMBL9923785 | 0.68 | KIT (0.39) | PTGS2MEN1KMT2ARAF1MAPK14 | |
| SCHEMBL1980287 | 0.68 | MTNR1B (0.68) | RAF1MTNR1AMTNR1BPDK1PDK2 | |
| SCHEMBL17571139 | 0.68 | GAA (0.57) | MEN1KMT2AS1PR4S1PR1S1PR3 | |
| SCHEMBL8200423 | 0.68 | L3MBTL1 (0.67) | MEN1KMT2APDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |