Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457128 | 0.78 | SLC5A1 (0.62) | F2RL1L3MBTL1LMNAMAPTNFKB1 | |
| SCHEMBL9902245 | 0.78 | ALDH1A1 (0.58) | LMNAMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL1445627 | 0.75 | F2RL1 (0.73) | F2RL1L3MBTL1LMNAMAPTNFKB1 | |
| SCHEMBL14877832 | 0.75 | CALM1 (0.62) | F2RL1L3MBTL1LMNAMAPTNFKB1 | |
| SCHEMBL2172184 | 0.75 | KMT2A (0.66) | F2RL1L3MBTL1LMNAMAPTALDH1A1 | |
| SCHEMBL11246900 | 0.75 | CALM1 (0.62) | F2RL1L3MBTL1LMNAMAPTNFKB1 | |
| SCHEMBL11424136 | 0.74 | F2RL1 (0.57) | F2RL1L3MBTL1LMNAMAPTNFKB1 | |
| SCHEMBL28271408 | 0.73 | KMT2A (0.72) | F2RL1L3MBTL1LMNAMAPTALDH1A1 | |
| SCHEMBL14877841 | 0.73 | NFKB1 (0.57) | F2RL1L3MBTL1LMNAMAPTNFKB1 | |
| SCHEMBL9947512 | 0.73 | KMT2A (0.48) | LMNAMAPTALDH1A1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10188592-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2019-01-29 | — | — | US | disclosed |
| EP-2648689-B1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| US-20170014325-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-01-19 | — | — | US | disclosed |
| US-20170014325-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-01-19 | — | — | US | disclosed |
| US-9499508-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| US-9499508-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| US-20130261175-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2013-10-03 | — | — | US | disclosed |
| US-20130261175-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2013-10-03 | — | — | US | disclosed |
| WO-2012076109-A2 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170014325-A1 | 2-PYRONES | PYCR1, CYP17A1, CYP11B2 | F2RL1 2729/4885L3MBTL1 4531/4885LMNA 260/4885 |
| US-20130261175-A1 | 2-PYRONES | PYCR1, CYP17A1, CYP11B2 | F2RL1 2729/4885L3MBTL1 4531/4885LMNA 260/4885 |
| US-10188592-B2 | 2-pyrones | PYCR1, CYP17A1, CYP11B2 | F2RL1 2729/4885L3MBTL1 4531/4885LMNA 260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.