SCHEMBL9909122

SCHEMBL9909122

Cc1ccc(OC(F)=C(F)F)cc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.52
ACHE P22303 3/20 0.44
ALDH1A1 P00352 2/20 0.41
GAA P10253 2/20 0.39
MAPT P10636 2/20 0.39
KDM4E B2RXH2 1/20 0.39
THRB P10828 1/20 0.39
BCHE P06276 1/20 0.39
TDP1 Q9NUW8 2/20 0.38
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38
TEAD4 Q15561 1/20 0.38
KMT2A Q03164 4/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
POLB P06746 1/20 0.37
MEN1 O00255 1/20 0.37
WDR5 P61964 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4530562 0.87 RAB9A (0.35) LMNAALDH1A1MAPTTDP1KMT2A
SCHEMBL11956141 0.84 LMNA (0.56) LMNAACHEALDH1A1GAAMAPT
SCHEMBL13577644 0.81 ESR2 (0.44) LMNAACHEALDH1A1GAAMAPT
SCHEMBL9169744 0.81 CA1 (0.52) LMNAACHEALDH1A1GAAMAPT
SCHEMBL2287929 0.80 LMNA (0.56) LMNAACHEALDH1A1GAAMAPT
SCHEMBL12833374 0.80 KMT2A (0.43) ALDH1A1MAPTTDP1CYP3A4TSHR
SCHEMBL12833375 0.80 KIF11 (0.39) LMNAGAAKDM4EKMT2AMEN1
SCHEMBL1505815 0.80 KIF11 (0.39) LMNAGAAKDM4EKMT2AMEN1
SCHEMBL8934991 0.80 KIF11 (0.39) LMNAGAAKDM4EKMT2AMEN1
SCHEMBL1505923 0.78 MEN1 (0.48) LMNAALDH1A1GAAMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230383186-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-11-30 US disclosed
US-10000700-B2 Nematic liquid crystal composition DIC CORPORATION (JP) 2018-06-19 US disclosed
EP-2797871-B1 CROSSLINKABLE ARYLAMINE COMPOUNDS NISSAN CHEMICAL IND LTD (JP) 2018-05-09 EP disclosed
US-20170198219-A1 NEMATIC LIQUID CRYSTAL COMPOSITION DIC CORPORATION (JP) 2017-07-13 US disclosed
US-20150094437-A1 CROSSLINKABLE ARYLAMINE COMPOUNDS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-04-02 US disclosed
US-20150094437-A1 CROSSLINKABLE ARYLAMINE COMPOUNDS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-04-02 US disclosed
US-8921358-B2 Apoptosis signal-regulating kinase 1 inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-12-30 US disclosed
US-8921358-B2 Apoptosis signal-regulating kinase 1 inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-12-30 US disclosed
US-8580401-B2 Curable material and its application ETERNAL CHEMICAL CO., LTD. (TW) 2013-11-12 US disclosed
US-20130203731-A1 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) 2013-08-08 US disclosed
WO-2010082924-A1 CROSS-LINKABLE COPPER PHTHALOCYANINE COMPLEXES UNIVERSAL DISPLAY CORPORATION (US) 2010-07-22 WO disclosed
WO-2010068205-A1 CROSS LINKED ORGANIC CONDUCTIVE LAYER HCF PARTNERS, L.P. (US) 2010-06-17 WO disclosed
WO-2010059646-A2 AMINOBENZENE COMPOSITIONS AND RELATED DEVICES AND METHODS PLEXTRONICS, INC. (US) 2010-05-27 WO disclosed
US-20090192263-A1 TRIFLUOROVINYL AROMATIC CONTAINING POLY(ALKYL ETHER) PREPOLYMERS BAUSCH & LOMB MEXICO, S.A. DE C.V. (MX) 2009-07-30 US disclosed
US-7538160-B2 Trifluorovinyl aromatic containing poly(alkyl ether) prepolymers BAUSCH & LOMB INCORPORATED (US) 2009-05-26 US disclosed
US-7402634-B2 Perfluorocyclobutane copolymers BAUSCH AND LAMB INCORPORATED (US) 2008-07-22 US disclosed
US-20070154429-A1 PERFLUOROCYCLOBUTANE CROSSLINKED HYDROGELS ZIMMER, INC. (US) 2007-07-05 US disclosed
US-7214475-B2 Partially polymerizing a blend of a bis(trifluorovinyl) derivative of a group of a group 14 metal (especially Si or Ge) compound, another bis(trifluorovinyl) compound, a photocurable compound and a photoinitiator; depositing product on a substrate; exposing to effect photocuring; and curing the product MOMENTIVE PERFORMANCE MATERIALS INC. 2007-05-08 US disclosed
US-7214475-B2 Partially polymerizing a blend of a bis(trifluorovinyl) derivative of a group of a group 14 metal (especially Si or Ge) compound, another bis(trifluorovinyl) compound, a photocurable compound and a photoinitiator; depositing product on a substrate; exposing to effect photocuring; and curing the product MOMENTIVE PERFORMANCE MATERIALS INC. 2007-05-08 US disclosed
US-20070004897-A1 Trifluorovinyl aromatic containing poly(alkyl ether) prepolymers BAUSCH & LOMB INCORPORATED 2007-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130203731-A1 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS BAX, BCL2, BAD LMNA 1347/4885ACHE 4638/4885ALDH1A1 2965/4885
US-20070154429-A1 PERFLUOROCYCLOBUTANE CROSSLINKED HYDROGELS SYVN1, EPHA2, FGFR2 LMNA 4355/4885ACHE 2873/4885ALDH1A1 904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.