SCHEMBL1505923

SCHEMBL1505923

Oc1ccc(OC(F)=C(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
ESR2 Q92731 2/20 0.48
ESR1 P03372 2/20 0.48
LTA4H P09960 3/20 0.41
NR1H2 P55055 1/20 0.41
BAX Q07812 1/20 0.41
MAPT P10636 4/20 0.40
KDM4E B2RXH2 3/20 0.40
BLM P54132 2/20 0.40
LMNA P02545 2/20 0.40
HIF1A Q16665 2/20 0.40
NPC1 O15118 1/20 0.40
CA12 O43570 1/20 0.40
GMNN O75496 1/20 0.40
ALDH1A1 P00352 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA3 P07451 1/20 0.40
CYP3A4 P08684 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13422323 0.93 ESR2 (0.50) MEN1KMT2AESR2ESR1LTA4H
SCHEMBL4530562 0.89 RAB9A (0.35) MEN1KMT2AESR2ESR1MAPT
SCHEMBL9006421 0.88 APP (0.50) MEN1KMT2AESR1LTA4HMAPT
SCHEMBL9006417 0.88 APP (0.50) MEN1KMT2AESR1LTA4HMAPT
SCHEMBL12834528 0.84 ESR1 (0.50) MEN1KMT2AESR2ESR1LTA4H
SCHEMBL12833375 0.82 KIF11 (0.39) MEN1KMT2AESR2ESR1KDM4E
SCHEMBL12833374 0.82 KMT2A (0.43) MEN1KMT2AESR2ESR1LTA4H
SCHEMBL1505815 0.82 KIF11 (0.39) MEN1KMT2AESR2ESR1KDM4E
SCHEMBL8934991 0.82 KIF11 (0.39) MEN1KMT2AESR2ESR1KDM4E
SCHEMBL13422349 0.80 SENP1 (0.50) MEN1KMT2AESR2MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3613810-A1 ARTICLES AND COMPOSITIONS COMPRISING HOST POLYMERS AND CHROMOPHORES AND METHODS OF PRODUCING THE SAME General Dynamics Mission Systems, Inc. (US) 2020-02-26 EP disclosed
US-20200048428-A1 ARTICLES AND COMPOSITIONS COMPRISING HOST POLYMERS AND CHROMOPHORES AND METHODS OF PRODUCING THE SAME GENERAL DYNAMICS MISSION SYSTEMS, INC. 2020-02-13 US disclosed
US-20110245429-A1 Cross Linked Organic Conductive Layer GOUGH, NEIL (GB) 2011-10-06 US disclosed
US-20110245429-A1 Cross Linked Organic Conductive Layer GOUGH, NEIL (GB) 2011-10-06 US disclosed
US-7897693-B2 Proton conductive polymer electrolytes and fuel cells GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2011-03-01 US disclosed
WO-2010068205-A1 CROSS LINKED ORGANIC CONDUCTIVE LAYER HCF PARTNERS, L.P. (US) 2010-06-17 WO disclosed
US-7674876-B2 Synthesis of novel monomers containing the trifluorovinylidene group and the cyanato group and polymers thereof Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2010-03-09 US disclosed
US-7674876-B2 Synthesis of novel monomers containing the trifluorovinylidene group and the cyanato group and polymers thereof Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2010-03-09 US disclosed
US-20090281262-A1 PROTON CONDUCTIVE POLYMER ELECTROLYTES AND FUEL CELLS GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2009-11-12 US disclosed
EP-0428709-B1 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS DOW CHEMICAL CO (US) 1995-05-24 EP disclosed
US-5198513-A Compounds for engineering thermoplastics or dimers THE DOW CHEMICAL COMPANY (US) 1993-03-30 US disclosed
US-5037919-A Endcapper for polyesters, polycarbonates, polyamides and polyethers THE DOW CHEMICAL COMPANY (US) 1991-08-06 US disclosed
EP-0428709-A1 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
WO-1990015042-A2 REACTIVE COMPOUNDS CONTAINING PERFLUOROVINYL GROUPS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245429-A1 Cross Linked Organic Conductive Layer GJB2, GJA1, KCNH3 MEN1 3648/4885KMT2A 1697/4885ESR2 863/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.