Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 14/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 14/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978090 | 0.92 | LMNA (0.48) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL16330567 | 0.91 | EPHX2 (0.48) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL12917527 | 0.91 | KIF11 (0.50) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL6909931 | 0.91 | L3MBTL1 (0.46) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL3158110 | 0.88 | HDAC3 (0.46) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL23299715 | 0.87 | LMNA (0.52) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL2806972 | 0.86 | L3MBTL1 (0.43) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL29455253 | 0.85 | HDAC6 (0.45) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL12532536 | 0.84 | KIF11 (0.57) | HDAC3HDAC1 | |
| SCHEMBL16647700 | 0.84 | CYP3A4 (0.48) | HDAC6HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160206702-A1 | PEGylated Recombinant Human Growth Hormone Compounds | ASCENDIS PHARMA GROWTH DISORDERS DIVISION A/S (DK) | 2016-07-21 | — | — | US | disclosed |
| US-9272048-B2 | PEGylated recombinant human growth hormone compounds | ASCENDIS PHARMA GROWTH DISORDERS DIVISION A/S (DK) | 2016-03-01 | — | — | US | disclosed |
| US-9272048-B2 | PEGylated recombinant human growth hormone compounds | ASCENDIS PHARMA GROWTH DISORDERS DIVISION A/S (DK) | 2016-03-01 | — | — | US | disclosed |
| US-20120058084-A1 | Interferon Alpha Carrier Prodrugs | ASCENDIS PHARMA AS (DK) | 2012-03-08 | — | — | US | disclosed |
| US-20120058084-A1 | Interferon Alpha Carrier Prodrugs | ASCENDIS PHARMA AS (DK) | 2012-03-08 | — | — | US | disclosed |
| US-20110112021-A1 | PEGYLATED RECOMBINANT HUMAN GROWTH HORMONE COMPOUNDS | ASCENDIS PHARMA AS (DK) | 2011-05-12 | — | — | US | disclosed |
| US-20110112021-A1 | PEGYLATED RECOMBINANT HUMAN GROWTH HORMONE COMPOUNDS | ASCENDIS PHARMA AS (DK) | 2011-05-12 | — | — | US | disclosed |
| WO-2010100220-A1 | INTERFERON ALPHA CARRIER PRODRUGS | ASCENDIS PHARMA AS (DK) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112021-A1 | PEGYLATED RECOMBINANT HUMAN GROWTH HORMONE COMPOUNDS | GHRHR, GHITM, GHSR | HDAC6 2149/4885HDAC3 1635/4885HDAC1 1390/4885 |
| US-20160206702-A1 | PEGylated Recombinant Human Growth Hormone Compounds | GHRHR, GHITM, GHSR | HDAC6 2149/4885HDAC3 1635/4885HDAC1 1390/4885 |
| US-20120058084-A1 | Interferon Alpha Carrier Prodrugs | IFNG, IFNAR1, IRF3 | HDAC6 2459/4885HDAC3 2149/4885HDAC1 4061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.