Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915302 | 0.83 | TP53 (0.40) | TP53TSHRPLA2G2AALDH1A1HPGD | |
| SCHEMBL12949557 | 0.78 | COMT (0.39) | TP53TSHRTYRGAAHTT | |
| SCHEMBL2115801 | 0.77 | SRD5A2 (0.51) | — | |
| SCHEMBL12968954 | 0.76 | RAB9A (0.50) | TP53PLA2G4B | |
| SCHEMBL13555567 | 0.74 | PTGDR2 (0.34) | TP53TSHRGAAHTT | |
| SCHEMBL12949565 | 0.72 | BRD4 (0.33) | ALDH1A1HPGD | |
| SCHEMBL8134142 | 0.72 | SMPD1 (0.39) | PLA2G2AALDH1A1HPGD | |
| SCHEMBL13555566 | 0.72 | NR1H2 (0.34) | TP53TSHRTYRGAAHTT | |
| SCHEMBL16747451 | 0.71 | ALDH1A1 (0.40) | TP53TSHRALDH1A1 | |
| SCHEMBL9915359 | 0.70 | COMT (0.40) | TP53TSHRALDH1A1TYRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | TP53 4737/4885TSHR 4478/4885PLA2G2A 1380/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | TP53 4737/4885TSHR 4478/4885PLA2G2A 1380/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | TP53 4737/4885TSHR 4478/4885PLA2G2A 1380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.