Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16747360 | 0.87 | MEN1 (0.41) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL9915434 | 0.86 | NR1H4 (0.44) | NR1H4PTPN11LMNASMN1; SMN2TSHR | |
| SCHEMBL16747359 | 0.83 | MAPT (0.44) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL9915302 | 0.82 | TP53 (0.40) | PTPN11TSHRTP53PLA2G4BHPGD | |
| SCHEMBL9915523 | 0.81 | C5AR1 (0.39) | MEN1KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL14124973 | 0.80 | PPIA (0.48) | NR1H4MEN1KMT2AMAPTLMNA | |
| SCHEMBL16747451 | 0.79 | ALDH1A1 (0.40) | MEN1KMT2ALMNATSHRTP53 | |
| SCHEMBL14136527 | 0.79 | PPARD (0.43) | NR1H4PTPN11MAPTLMNASMN1; SMN2 | |
| SCHEMBL9915325 | 0.78 | SMN1; SMN2 (0.43) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL16747452 | 0.74 | PTPRC (0.36) | MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | NR1H4 277/4885MEN1 2023/4885KMT2A 608/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | NR1H4 277/4885MEN1 2023/4885KMT2A 608/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | NR1H4 277/4885MEN1 2023/4885KMT2A 608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.