Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924215 | 0.85 | SLC6A9 (0.41) | LMNANPC1RAB9ATP53MDM2 | |
| SCHEMBL17206620 | 0.79 | GRM4 (0.39) | LMNANPC1RAB9ATP53MDM2 | |
| SCHEMBL17206624 | 0.78 | CYP2D6 (0.44) | LMNANPC1RAB9AGRM4SLC6A9 | |
| SCHEMBL9924222 | 0.78 | CYP2D6 (0.44) | LMNANPC1RAB9AGRM4SLC6A9 | |
| SCHEMBL9924261 | 0.77 | TRPV1 (0.42) | POLBGRM4SLC6A9MC5RMEN1 | |
| SCHEMBL9924090 | 0.74 | APOB (0.40) | POLBTP53MDM2GRM4SLC6A9 | |
| SCHEMBL9924083 | 0.73 | NPC1 (0.44) | NPC1RAB9ATP53MDM2GRM4 | |
| SCHEMBL9924087 | 0.73 | HSD11B1 (0.39) | LMNAGRM4SLC6A9MC5RSLC6A5 | |
| SCHEMBL9924086 | 0.72 | ALDH1A1 (0.44) | LMNAPOLBGRM4SLC6A9SLC6A5 | |
| SCHEMBL9924333 | 0.71 | NPC1 (0.44) | NPC1RAB9APOLBGRM4MC5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |