Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600202 | 0.88 | MMP8 (0.46) | RENMMP13ITGA4ITGB7AKT1 | |
| SCHEMBL8724329 | 0.87 | ITGA4 (0.49) | RENMMP13ITGA4ITGB7ATM | |
| SCHEMBL8724334 | 0.87 | ITGA4 (0.49) | RENMMP13ITGA4ITGB7ATM | |
| SCHEMBL12600955 | 0.87 | ITGA4 (0.49) | RENMMP13ITGA4ITGB7ATM | |
| SCHEMBL65502 | 0.85 | MMP13 (0.46) | RENMMP13ITGA4ITGB7ATM | |
| SCHEMBL2476924 | 0.85 | MMP13 (0.46) | RENMMP13ITGA4ITGB7ATM | |
| SCHEMBL1401042 | 0.85 | MMP13 (0.46) | RENMMP13ITGA4ITGB7ATM | |
| SCHEMBL16715161 | 0.84 | CTSS (0.46) | RENMMP13ITGA4ITGB7ATM | |
| SCHEMBL16715162 | 0.84 | CTSS (0.46) | RENMMP13ITGA4ITGB7ATM | |
| SCHEMBL8164713 | 0.84 | REN (0.48) | RENMMP13ITGA4ITGB7AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011011483-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-01-27 | — | — | WO | disclosed |