Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | KCNK13 | Q9HB14 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21018568 | 0.80 | GABRA2 (0.38) | TRPV4 | |
| SCHEMBL45880 | 0.80 | — | — | |
| SCHEMBL24468445 | 0.79 | P2RX3 (0.32) | — | |
| SCHEMBL30612260 | 0.78 | TRPV4 (0.39) | TRPV4KCNK13 | |
| SCHEMBL335563 | 0.78 | TRPV4 (0.39) | TRPV4KCNK13 | |
| SCHEMBL27813564 | 0.78 | TRPV4 (0.34) | TRPV4KCNK13 | |
| SCHEMBL31613901 | 0.78 | NOTUM (0.39) | TRPV4KCNK13 | |
| SCHEMBL30721121 | 0.78 | TRPV4 (0.34) | TRPV4KCNK13 | |
| SCHEMBL14448163 | 0.78 | TRPV4 (0.34) | TRPV4KCNK13 | |
| SCHEMBL7999604 | 0.78 | TRPV4 (0.34) | TRPV4KCNK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210395243-A1 | PESTICIDAL COMPOUNDS | BASF SE (DE) | 2021-12-23 | — | — | US | disclosed |
| CN-106661023-B | Pesticidally active heterocyclic derivatives with sulphur containing substituents | 先正达参股股份有限公司 | 2019-05-28 | — | — | CN | disclosed |
| CN-106661023-A | Pesticidally active heterocyclic derivatives with sulphur containing substituents | 先正达参股股份有限公司 | 2017-05-10 | — | — | CN | disclosed |
| US-20120149674-A1 | Diaryl Substituted Alkanes | MERCK SHARPE & DOHME CORP. (US) | 2012-06-14 | — | — | US | disclosed |
| US-8124628-B2 | Diaryl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | disclosed |
| US-20090258851-A1 | DIARYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | TRPV4 778/4885PDE4B 766/4885KCNK13 3546/4885 |
| US-20210395243-A1 | PESTICIDAL COMPOUNDS | NIT2, PNMT, DDT | TRPV4 915/4885PDE4B 791/4885KCNK13 2333/4885 |
| US-20120149674-A1 | Diaryl Substituted Alkanes | ALOX5, ALOX15, LTB4R2 | TRPV4 1060/4885PDE4B 795/4885KCNK13 3350/4885 |
| US-20090258851-A1 | DIARYL SUBSTITUTED ALKANES | ALOX5, ALOX15, LTB4R2 | TRPV4 1060/4885PDE4B 795/4885KCNK13 3350/4885 |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | TRPV4 1080/4885PDE4B 788/4885KCNK13 3699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.