Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.30 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.30 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.30 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.30 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.30 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9964985 | 0.84 | MAPT (0.46) | ASH1LIDO1ALDH1A1MEN1MAPT | |
| SCHEMBL9970790 | 0.83 | ASH1L (0.38) | ASH1LIDO1ALDH1A1MEN1MAPT | |
| SCHEMBL9965020 | 0.82 | LMNA (0.45) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9964964 | 0.80 | ROCK2 (0.44) | — | |
| SCHEMBL9970789 | 0.80 | HTR1B (0.41) | ASH1LALDH1A1TDP1 | |
| SCHEMBL9964987 | 0.76 | SMN1; SMN2 (0.46) | TDP1 | |
| SCHEMBL9965019 | 0.75 | NOS3 (0.46) | ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL6194739 | 0.74 | IDO1 (0.50) | IDO1RECQLALDH1A1MEN1MAPT | |
| SCHEMBL9965026 | 0.74 | KDM4E (0.38) | ALDH1A1 | |
| SCHEMBL9964986 | 0.74 | BRD4 (0.49) | ALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651516-B1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'ORÉAL (FR) | 2017-06-14 | — | — | EP | claimed |
| EP-2651386-A2 | DYE COMPOSITION COMPRISING AT LEAST FOUR DYE PRECURSORS INCLUDING AT LEAST ONE OXIDATION BASE AND AT LEAST ONE COUPLER | L'Oréal (FR) | 2013-10-23 | — | — | EP | claimed |
| WO-2012080289-A2 | DYE COMPOSITION COMPRISING AT LEAST FOUR DYE PRECURSORS INCLUDING AT LEAST ONE OXIDATION BASE AND AT LEAST ONE COUPLER | L'OREAL (FR) | 2012-06-21 | — | — | WO | claimed |
| WO-2012080285-A2 | DYE COMPOSITION COMPRISING A SECONDARY PARA-PHENYLENEDIAMINE OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'OREAL (FR) | 2012-06-21 | — | — | WO | claimed |
| EP-2651516-B1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'ORÉAL (FR) | 2017-06-14 | — | — | EP | disclosed |
| EP-2651516-B1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'ORÉAL (FR) | 2017-06-14 | — | — | EP | disclosed |
| US-9220671-B2 | Dye composition comprising at least four dye precursors including at least one oxidation base and at least one coupler | L'OREAL (FR) | 2015-12-29 | — | — | US | disclosed |
| US-9220671-B2 | Dye composition comprising at least four dye precursors including at least one oxidation base and at least one coupler | L'OREAL (FR) | 2015-12-29 | — | — | US | disclosed |
| US-9125834-B2 | Dye composition comprising a heterocyclic oxidation base and a 4-aminoindole coupler | L'OREAL (FR) | 2015-09-08 | — | — | US | disclosed |
| US-9125834-B2 | Dye composition comprising a heterocyclic oxidation base and a 4-aminoindole coupler | L'OREAL (FR) | 2015-09-08 | — | — | US | disclosed |
| US-20140259454-A1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'OREAL (FR) | 2014-09-18 | — | — | US | disclosed |
| US-20140259454-A1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'OREAL (FR) | 2014-09-18 | — | — | US | disclosed |
| EP-2651889-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'Oréal (FR) | 2013-10-23 | — | — | EP | disclosed |
| US-20130263390-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'OREAL (FR) | 2013-10-10 | — | — | US | disclosed |
| US-20130263390-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'OREAL (FR) | 2013-10-10 | — | — | US | disclosed |
| WO-2012080289-A2 | DYE COMPOSITION COMPRISING AT LEAST FOUR DYE PRECURSORS INCLUDING AT LEAST ONE OXIDATION BASE AND AT LEAST ONE COUPLER | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080285-A2 | DYE COMPOSITION COMPRISING A SECONDARY PARA-PHENYLENEDIAMINE OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080321-A2 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080288-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080288-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | L'OREAL (FR) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140259454-A1 | DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND A 4-AMINOINDOLE COUPLER | KRT18, NDUFS5, NDUFS3 | ASH1L 2011/4885IDO1 424/4885P2RX7 2043/4885 |
| US-20130263390-A1 | 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES | KRT18, AADAT, KMO | ASH1L 2506/4885IDO1 58/4885P2RX7 4421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.